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Dietary supplementation with mulberry leaf flavonoids and carnosic acid complex enhances the growth performance and antioxidant capacity via regulating the p38 MAPK/Nrf2 pathway.
Liu, Chunming; Huang, Hui; Chen, Yulian; Zhou, Yingjun; Meng, Tiantian; Tan, Bihui; He, Wenxiang; Fu, Xiaoqin; Xiao, Dingfu.
Afiliación
  • Liu C; College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
  • Huang H; College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
  • Chen Y; College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
  • Zhou Y; College of Xiangya Pharmaceutical Sciences, Central South University, Changsha, China.
  • Meng T; Geneham Pharmaceutical Co., Ltd., Changsha, China.
  • Tan B; College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
  • He W; College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
  • Fu X; College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
  • Xiao D; College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
Front Nutr ; 11: 1428577, 2024.
Article en En | MEDLINE | ID: mdl-39139650
ABSTRACT

Introduction:

This study aimed to investigate the regulatory effects of mulberry leaf flavonoids and carnosic acid complex (MCC) on the growth performance, intestinal morphology, antioxidant, and p38 MAPK/Nrf2 pathway in broilers.

Methods:

A total of 256 healthy 8-day-old female yellow-feathered broilers were randomly divided into 4 equal groups a control group (CON) fed a basal diet, an antibiotic group (CTC) supplemented with 50 mg/kg chlortetracycline, and two experimental groups (MCC75, MCC150) fed basal diets with 75 mg/kg and 150 mg/kg of MCC, respectively. The experiment lasted for 56 days, with days 1-28 designated as the initial phase and days 29-56 as the growth phase.

Results:

The results on the growth performance showed that diets supplemented with MCC and CTC decreased the feed-to-gain ratio (F/G), diarrhea rate, and death rate, while significantly increasing the average daily weight gain (ADG) (p < 0.05). Specifically, the MCC150 group enhanced intestinal health, indicated by reduced crypt depth and increased villus height-to-crypt depth ratio (V/C) as well as amylase activity in the jejunum. Both the MCC and CTC groups exhibited increased villus height and V/C ratio in the ileal (p < 0.05). Additionally, all treated groups showed elevated serum total antioxidant capacity (T-AOC), and significant increases in catalase (CAT) and glutathione peroxidase (GSH-Px) activities were observed in both the MCC150 and CTC groups. Molecular analysis revealed an upregulation of the jejunal mRNA expression levels of PGC-1α, Nrf2, and Keap1 in the MCC and CTC groups, as well as an upregulation of ileum mRNA expression levels of P38, PGC-1α, Nrf2, and Keap1 in the MCC150 group, suggesting activation of the p38-MAPK/Nrf2 pathway.

Discussion:

These findings indicate that dietary supplementation with MCC, particularly at a dosage of 150 mg/kg, may serve as a viable antibiotic alternative, enhancing growth performance, intestinal health, and antioxidant capacity in broilers by regulating the p38-MAPK/Nrf2 pathway.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Nutr Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Nutr Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza