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Circulating miR-122-5p, miR-151a-3p, miR-126-5p and miR-21-5p as potential predictive biomarkers for Metabolic Dysfunction-Associated Steatotic Liver Disease assessment.
Tobaruela-Resola, Ana Luz; Milagro, Fermín I; Elorz, Mariana; Benito-Boillos, Alberto; Herrero, José I; Mogna-Peláez, Paola; Tur, Josep A; Martínez, J Alfredo; Abete, Itziar; Zulet, M Ángeles.
Afiliación
  • Tobaruela-Resola AL; Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008, Pamplona, Spain.
  • Milagro FI; Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008, Pamplona, Spain.
  • Elorz M; Navarra Institute for Health Research (IdiSNA), 31008, Pamplona, Spain.
  • Benito-Boillos A; Biomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
  • Herrero JI; Navarra Institute for Health Research (IdiSNA), 31008, Pamplona, Spain.
  • Mogna-Peláez P; Department of Radiology, Clínica Universidad de Navarra, 31008, Pamplona, Spain.
  • Tur JA; Navarra Institute for Health Research (IdiSNA), 31008, Pamplona, Spain.
  • Martínez JA; Department of Radiology, Clínica Universidad de Navarra, 31008, Pamplona, Spain.
  • Abete I; Navarra Institute for Health Research (IdiSNA), 31008, Pamplona, Spain.
  • Zulet MÁ; Liver Unit, Clínica Universidad de Navarra, 31008, Pamplona, Spain.
J Physiol Biochem ; 2024 Aug 14.
Article en En | MEDLINE | ID: mdl-39138826
ABSTRACT
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a worldwide leading cause of liver-related associated morbidities and mortality. Currently, there is a lack of reliable non-invasive biomarkers for an accurate of MASLD. Hence, this study aimed to evidence the functional role of miRNAs as potential biomarkers for MASLD assessment. Data from 55 participants with steatosis (MASLD group) and 45 without steatosis (control group) from the Fatty Liver in Obesity (FLiO) Study (NCT03183193) were analyzed. Anthropometrics and body composition, biochemical and inflammatory markers, lifestyle factors and liver status were evaluated. Circulating miRNA levels were measured by RT-PCR. Circulating levels of miR-122-5p, miR-151a-3p, miR-126-5p and miR-21-5p were significantly increased in the MASLD group. These miRNAs were significantly associated with steatosis, liver stiffness and hepatic fat content. Logistic regression analyses revealed that miR-151a-3p or miR-21-5p in combination with leptin showed a significant diagnostic accuracy for liver stiffness obtaining an area under the curve (AUC) of 0.76 as well as miR-151a-3p in combination with glucose for hepatic fat content an AUC of 0.81. The best predictor value for steatosis was obtained by combining miR-126-5p with leptin, presenting an AUC of 0.95. Circulating miRNAs could be used as a non-invasive biomarkers for evaluating steatosis, liver stiffness and hepatic fat content, which are crucial in determining MASLD. CLINICAL TRIAL REGISTRATION • Trial registration number NCT03183193 ( www.clinicaltrials.gov ). • Date of registration 12/06/2017.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Physiol Biochem Asunto de la revista: BIOQUIMICA / FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: España
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Physiol Biochem Asunto de la revista: BIOQUIMICA / FISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: España