Your browser doesn't support javascript.
loading
Development of a SnO2-based 44Ti/44Sc generator for medical applications.
Schmidt, Christine E; Groveman, Sam; Sanders, Vanessa A; Cutler, Cathy S; Shusterman, Jennifer A; Deri, Melissa A.
Afiliación
  • Schmidt CE; PhD Program in Chemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA; Department of Chemistry, Lehman College, CUNY, Bronx, NY 10468, USA.
  • Groveman S; Department of Chemistry and Environmental Science, Medgar Evers College, CUNY, Brooklyn, NY 11225, USA.
  • Sanders VA; Isotope Research and Production Department, Brookhaven National Laboratory, Upton, NY, 11973, USA.
  • Cutler CS; Isotope Research and Production Department, Brookhaven National Laboratory, Upton, NY, 11973, USA.
  • Shusterman JA; Department of Chemistry, Hunter College, CUNY, New York, NY 10065, USA; Nuclear and Chemical Sciences Division, Lawrence Livermore National Laboratory, Livermore, CA, 94550, USA.
  • Deri MA; PhD Program in Chemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA; Department of Chemistry, Lehman College, CUNY, Bronx, NY 10468, USA. Electronic address: MELISSA.DERI@lehman.cuny.edu.
J Chromatogr A ; 1732: 465245, 2024 Sep 13.
Article en En | MEDLINE | ID: mdl-39137585
ABSTRACT
Towards application of 44Sc for diagnostic nuclear medicine, a 44Ti/44Sc generator based on an inorganic resin has been evaluated. Unlike other radionuclide generators used for medical applications, the long-term retention of the parent 44Ti is vital due to its long half life. Herein, tin dioxide (SnO2), a robust inorganic-based resin, has been synthesized and used as the stationary phase for a 44Ti/44Sc generator. The sorption behavior of 44Ti/44Sc was tested on SnO2 with varying acids, concentrations, and times. Preliminary batch study results showed >88 % 44Ti retention to the resin at lower acid concentrations (0.05 M HNO3 and 0.05 M HCl). A pilot generator was evaluated for a year, demonstrating 85.3 ± 2.8 % 44Sc elution yields and 0.71 ± 0.14 % 44Ti breakthrough in 5 M HNO3. Based on capacity studies, a 7.4 MBq (200 µCi) upscaled generator system was constructed for further evaluation of the SnO2 resin stability and the efficacy of the eluted 44Sc for radiolabeling. 44Sc could be regularly eluted from this generator in 5 M HNO3 with an overall average radiochemical yield 84.7 ± 9.5 %. Post-elution processing of the 44Sc with DGA-normal resin removed all 44Ti present and allowed for high 44Sc-DOTA labeling yields of 94.2 ± 0.5 %. Overall, SnO2 has been shown to be a viable material for a 44Ti/44Sc generator.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Estaño Idioma: En Revista: J Chromatogr A Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Compuestos de Estaño Idioma: En Revista: J Chromatogr A Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos