Translational approach to establish the cardiometabolic health effects and mechanisms of action of fish nutrients-it takes a village.
Appl Physiol Nutr Metab
; 2024 Aug 13.
Article
en En
| MEDLINE
| ID: mdl-39137439
ABSTRACT
People use dietary supplements to offset nutritional deficiencies and manage metabolic dysfunction. While the beneficial effect of fish proteins on glucose homeostasis is well established, the ability of fish peptides to replicate the protein findings is less clear. With financial support from a programmatic Canadian Institutes of Health Research (CIHR) team grant, we aimed to identify salmon peptide fractions (SPF) with the potential to mitigate metabolic dysfunction. Additionally the grant aims included assessing whether vitamin D, a nutrient commonly found in salmon could potentiate the beneficial effects of salmon peptides. In parallel, technologies were developed to separate and filter the isolated peptides. We employed an integrative approach that combined nutritional interventions in animal models and human subjects to identify metabolic pathways regulated by salmon peptides and other fish nutrients. This combination of interdisciplinary expertise revealed that a SPF could be a therapeutic tool used in the prevention and management of cardiometabolic diseases. Herein, we present a perspective of our CIHR funded grant that utilized a translational approach to establish the cardiometabolic health effects and mechanisms of action of fish nutrients from animal models to clinical trials.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Appl Physiol Nutr Metab
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
FISIOLOGIA
/
MEDICINA ESPORTIVA
/
METABOLISMO
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Canadá