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Rational optimization of glycoprotein E (gE)-encoding mRNA for improved Varicella-zoster virus mRNA vaccine development.
Huang, Lulu; Zhang, Shun; Zhao, Tongyi; Cai, Ting; Bu, Lingling; Di, Zhenhua; Zhang, Yujie; Yang, Chen; Yang, Yong; Lin, Ang.
Afiliación
  • Huang L; Vaccine Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
  • Zhang S; Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing, People's Republic of China.
  • Zhao T; Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, People's Republic of China.
  • Cai T; Vaccine Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
  • Bu L; Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing, People's Republic of China.
  • Di Z; Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, People's Republic of China.
  • Zhang Y; Vaccine Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
  • Yang C; Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing, People's Republic of China.
  • Yang Y; Vaccine Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People's Republic of China.
  • Lin A; Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing, People's Republic of China.
Emerg Microbes Infect ; 13(1): 2392661, 2024 Dec.
Article en En | MEDLINE | ID: mdl-39137287
ABSTRACT
mRNA platform holds promise for next-generation Varicella-zoster Virus (VZV) vaccine development due to its high potency at inducing strong T-cell response. Built upon the design of our 1st-generation VZV mRNA vaccine that encodes for full-length gE antigen, in this study we reported on a novel combinatorial strategy to further optimize the gE-encoding mRNA sequence through signal peptide replacement, C-terminal modification, and insertion of mRNA-stabilizing motif, which collectively contributed to significantly improved vaccine immunogenicity. In adult mice, aged mice, and immunocompromised mice, this optimized VZV mRNA vaccine showed strong superiority in multiple aspects including the induction of gE-specific antibodies, specific memory B-cell response, as well as Th1-type T-cell response.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas del Envoltorio Viral / Herpesvirus Humano 3 / Anticuerpos Antivirales Límite: Animals / Female / Humans Idioma: En Revista: Emerg Microbes Infect Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas del Envoltorio Viral / Herpesvirus Humano 3 / Anticuerpos Antivirales Límite: Animals / Female / Humans Idioma: En Revista: Emerg Microbes Infect Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos