Neuroprotective actions of norepinephrine in neurological diseases.
Pflugers Arch
; 476(11): 1703-1725, 2024 Nov.
Article
en En
| MEDLINE
| ID: mdl-39136758
ABSTRACT
Precise control of norepinephrine (NE) levels and NE-receptor interaction is crucial for proper function of the brain. Much evidence for this view comes from experimental studies that indicate an important role for NE in the pathophysiology and treatment of various conditions, including cognitive dysfunction, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and sleep disorders. NE provides neuroprotection against several types of insults in multiple ways. It abrogates oxidative stress, attenuates neuroinflammatory responses in neurons and glial cells, reduces neuronal and glial cell activity, promotes autophagy, and ameliorates apoptotic responses to a variety of insults. It is beneficial for the treatment of neurodegenerative diseases because it improves the generation of neurotrophic factors, promotes neuronal survival, and plays an important role in the regulation of adult neurogenesis. This review aims to present the evidence supporting a principal role for NE in neuroprotection, and molecular mechanisms of neuroprotection.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Norepinefrina
/
Fármacos Neuroprotectores
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Pflugers Arch
Año:
2024
Tipo del documento:
Article
País de afiliación:
Irán
Pais de publicación:
Alemania