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Beautoide A, an Anti-Osteoclastogenic Steroid from Beauveria sp. NBUF147 Associated with an Irciniidae Sponge from the Marine Mesophotic Zone.
Ran, Jun Guang; Wang, Ping; Wang, Kun Hong; Wei, Ting-Ting; Liu, Yu-Ying; Wang, Ting Ting; Jin, Hai-Xiao; He, Shan.
Afiliación
  • Ran JG; Ningbo University, Department of marine drugs, , 169, , CHINA.
  • Wang P; Ningbo University, Department of marine drugs, , 169, , CHINA.
  • Wang KH; Ningbo University, Department of marine drugs, , 169, , CHINA.
  • Wei TT; Ningbo Institute of Industrial Technology Chinese Academy of Sciences, Department of marine drugs, , 169, , CHINA.
  • Liu YY; Ningbo University, Department of marine drugs, , 169, , CHINA.
  • Wang TT; Ningbo University, Department of marine drugs, , 169, , CHINA.
  • Jin HX; Ningbo University, Department of marine drugs, , 169, , CHINA.
  • He S; Ningbo University, Department of marine drugs, Fenghua road 818，Ningbo, 315832, Ningbo, CHINA.
Chem Biodivers ; : e202401689, 2024 Aug 13.
Article en En | MEDLINE | ID: mdl-39136520
ABSTRACT
Mesophotic coral ecosystems (MCEs), located at depths ranging from 30-150 m, host some of the most diverse yet least explored marine bioresources, particularly significant for the discovery of new bioactive molecules. The fungus Beauveria sp. NBUF147, associated with an Irciniidae sponge from the mesophotic zone at a depth of 82 m, underwent chemical investigation that led to the identification of one new sterol, beautoide A (1), and one reported sterol, 3ß,5α,9α-trihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (2). Their structures were determined from analysis of spectroscopic data and X-ray crystallography. Evaluation of biological activity in prednisolone-induced osteoporotic zebrafish showed that 1 was anti-osteoclastogenic in vivo at 3.0 µM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza