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The seasonal distribution of immune thrombotic thrombocytopenic purpura is influenced by geography: Epidemiologic findings from a multi-center analysis of 719 disease episodes.
Jacobs, Jeremy W; Stanek, Caroline G; Booth, Garrett S; Symeonidis, Argiris; Shih, Andrew W; Allen, Elizabeth S; Gavriilaki, Eleni; Grossman, Brenda J; Pavenski, Katerina; Moorehead, Amy; Peyvandi, Flora; Agosti, Pasquale; Mancini, Ilaria; Stephens, Laura D; Raval, Jay S; Mingot-Castellano, Maria Eva; Crowe, Elizabeth P; Daou, Laetitia; Pai, Menaka; Arnold, Donald M; Marques, Marisa B; Henrie, Ryan; Smith, Tyler W; Sreenivasan, Gayatri; Siniard, Rance C; Wallace, Lisa R; Yamada, Chisa; Duque, Miriam Andrea; Wu, Yanyun; Harrington, Thomas J; Byrnes, Diana M; Bitsani, Aikaterini; Davis, Amanda K; Robinson, Danielle H; Eichbaum, Quentin; Figueroa Villalba, Cristina A; Juskewitch, Justin E; Kaiafa, Georgia; Kapsali, Eleni; Klapper, Ellen; Perez-Alvarez, Ingrid; Klein, Monica S; Kotsiou, Nikolaos; Lalayanni, Chrysavgi; Mandala, Evdokia; Aldarweesh, Fatima; Alkhateb, Rahaf; Fortuny, Lisandro; Mellios, Zois; Papalexandri, Apostolia.
Afiliación
  • Jacobs JW; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
  • Stanek CG; Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Booth GS; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Symeonidis A; Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Shih AW; Hematology Division, Department of Internal Medicine, University Hospital of Patras, Patras, Greece.
  • Allen ES; Department of Hematology, Olympion General Hospital & Rehabilitation Center, Patras, Greece.
  • Gavriilaki E; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Grossman BJ; Department of Pathology and Laboratory Medicine, Vancouver Coastal Health Authority, Vancouver, BC, Canada.
  • Pavenski K; Department of Pathology, University of California San Diego, La Jolla, California, USA.
  • Moorehead A; Department of Hematology, Aristotle University of Thessaloniki and George Papanikolaou General Hospital, Thessaloniki, Greece.
  • Peyvandi F; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Agosti P; Department of Medicine, Department of Laboratory Medicine, St. Michael's Hospital, Toronto, ON, Canada.
  • Mancini I; Department of Medicine, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada.
  • Stephens LD; Department of Medicine, Department of Laboratory Medicine, St. Michael's Hospital, Toronto, ON, Canada.
  • Raval JS; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.
  • Mingot-Castellano ME; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.
  • Crowe EP; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.
  • Daou L; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.
  • Pai M; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy.
  • Arnold DM; Department of Pathology, University of California San Diego, La Jolla, California, USA.
  • Marques MB; Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
  • Henrie R; Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
  • Smith TW; Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla, Universidad de Sevilla, Sevilla, Spain.
  • Sreenivasan G; Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Siniard RC; Division of Transfusion Medicine, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Wallace LR; Department of Medicine, Department of Pathology & Molecular Medicine, McMaster University, Hamilton, ON, Canada.
  • Yamada C; Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada.
  • Duque MA; Michael G. DeGroote Centre for Transfusion Research, McMaster University, Hamilton, ON, Canada.
  • Wu Y; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Harrington TJ; Division of Hematology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Byrnes DM; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Bitsani A; Department of Pathology and Laboratory Medicine, Vancouver Coastal Health Authority, Vancouver, BC, Canada.
  • Davis AK; Division of Hematology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
  • Robinson DH; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Eichbaum Q; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Figueroa Villalba CA; Department of Pathology, Division of Transfusion Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Juskewitch JE; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Kaiafa G; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Kapsali E; Division of Hematology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Klapper E; Division of Hematology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
  • Perez-Alvarez I; Haematology Clinic and Bone Marrow Τransplantation Unit, National and Kapodistrian University of Athens, "Laiko" General Hospital, Athens, Greece.
  • Klein MS; Department of Haematology, The Alfred Hospital, Melbourne, VIC, Australia.
  • Kotsiou N; Department of Haematology, The Alfred Hospital, Melbourne, VIC, Australia.
  • Lalayanni C; Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Mandala E; Department of Laboratory Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
  • Aldarweesh F; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
  • Alkhateb R; 1st Medical Propedeutic Department of Internal Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Fortuny L; Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.
  • Mellios Z; Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Papalexandri A; Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Am J Hematol ; 99(11): 2063-2074, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39136282
ABSTRACT
Prior studies have suggested that immune thrombotic thrombocytopenic purpura (iTTP) may display seasonal variation; however, methodologic limitations and sample sizes have diminished the ability to perform a rigorous assessment. This 5-year retrospective study assessed the epidemiology of iTTP and determined whether it displays a seasonal pattern. Patients with both initial and relapsed iTTP (defined as a disintegrin and metalloprotease with thrombospondin type motifs 13 activity <10%) from 24 tertiary centers in Australia, Canada, France, Greece, Italy, Spain, and the US were included. Seasons were defined as Northern Hemisphere-winter (December-February); spring (March-May); summer (June-August); autumn (September-November) and Southern Hemisphere-winter (June-August); spring (September-November); summer (December-February); autumn (March-May). Additional outcomes included the mean temperature in months with and without an iTTP episode at each site. A total of 583 patients experienced 719 iTTP episodes. The observed proportion of iTTP episodes during the winter was significantly greater than expected if equally distributed across seasons (28.5%, 205/719, 25.3%-31.9%; p = .03). Distance from the equator and mean temperature deviation both positively correlated with the proportion of iTTP episodes during winter. Acute iTTP episodes were associated with the winter season and colder temperatures, with a second peak during summer. Occurrence during winter was most pronounced at sites further from the equator and/or with greater annual temperature deviations. Understanding the etiologies underlying seasonal patterns of disease may assist in discovery and development of future preventative therapies and inform models for resource utilization.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estaciones del Año Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Am J Hematol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estaciones del Año Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Am J Hematol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos