All-in-One Nanohybrids Combining Sonodynamic Photodynamic and Photothermal Therapies.

Taydas, Dilsad; Özler, Muhammed Emre; Ergül, Mustafa; Sahin Inan, Zeynep Deniz; Sözmen, Fazli

Taydas, Dilsad; Özler, Muhammed Emre; Ergül, Mustafa; Sahin Inan, Zeynep Deniz; Sözmen, Fazli.

Afiliación

Taydas D; Nanotechnology Engineering Department, Faculty of Engineering, Sivas Cumhuriyet University, Sivas 58140, Türkiye.
Özler ME; Nanotechnology Engineering Department, Faculty of Engineering, Sivas Cumhuriyet University, Sivas 58140, Türkiye.
Ergül M; Biochemistry Department, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas 58140, Türkiye.
Sahin Inan ZD; Histology and Embryology Department, Faculty of Medicine, Sivas Cumhuriyet University, Sivas 58140, Türkiye.
Sözmen F; Nanotechnology Engineering Department, Faculty of Engineering, Sivas Cumhuriyet University, Sivas 58140, Türkiye.

ACS Appl Mater Interfaces ; 16(33): 43387-43399, 2024 Aug 21.

Article en En | MEDLINE | ID: mdl-39136145

ABSTRACT

ABSTRACT

A wide variety of methods are being developed to ultimately defeat cancer; while some of these strategies have shown highly positive results, there are serious obstacles to overcome to completely eradicate this disease. So, it is crucial to construct multifunctional nanostructures possessing intelligent capabilities that can be utilized to treat cancer. A possible strategy for producing these multifunctional nanostructures is to combine various cancer treatment techniques. Based on this point of view, we successfully synthesized multifunctional HCuS@Cu2S@Au-P(NIPAM-co-AAm)-PpIX nanohybrids. The peculiarities of these thermosensitive polymer-modified and protoporphyrin IX (PpIX)-loaded hollow nanohybrids are that they combine photodynamic therapy (PDT), sonodynamic therapy (SDT), and photothermal therapy (PTT) with an intelligent design. As an all-in-one nanohybrids, HCuS@Cu2S@Au-P(NIPAM-co-AAm)-PpIX nanohybrids were employed in the SDT-PDT-PTT combination therapy, which proved to have a synergistic therapeutic effect for in vitro tumor treatments against breast tumors.

Asunto(s)

Cobre; Fotoquimioterapia; Terapia Fototérmica; Protoporfirinas; Humanos; Cobre/química; Cobre/farmacología; Protoporfirinas/química; Protoporfirinas/farmacología; Protoporfirinas/uso terapéutico; Fármacos Fotosensibilizantes/química; Fármacos Fotosensibilizantes/farmacología; Fármacos Fotosensibilizantes/uso terapéutico; Fármacos Fotosensibilizantes/síntesis química; Oro/química; Femenino; Terapia por Ultrasonido/métodos; Nanoestructuras/química; Nanoestructuras/uso terapéutico; Neoplasias de la Mama/terapia; Neoplasias de la Mama/tratamiento farmacológico; Neoplasias de la Mama/patología; Línea Celular Tumoral; Sulfuros/química; Sulfuros/farmacología; Animales

Palabras clave

hollow nanohybrids; photodynamic therapy; photothermal therapy; sonodynamic therapy; thermosensitive polymer

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Protoporfirinas / Cobre / Terapia Fototérmica Límite: Animals / Female / Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google