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The Learning Curve for Holmium Laser Enucleation of the Prostate: A Single-Center Analysis of Surgical And Functional Outcomes.
Ditonno, Francesco; Bianchi, Alberto; Fumanelli, Francesca; Brancelli, Claudio; Malandra, Sarah; Rizzetto, Riccardo; Balzarro, Matteo; Rubilotta, Emanuele; Autorino, Riccardo; Bertolo, Riccardo; Veccia, Alessandro; Antonelli, Alessandro.
Afiliación
  • Ditonno F; Department of Urology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.
  • Bianchi A; Department of Urology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.
  • Fumanelli F; Department of Urology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.
  • Brancelli C; Department of Urology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.
  • Malandra S; Residency Program in Health Statistics and Biometrics, University of Verona, Verona, Italy.
  • Rizzetto R; Department of Urology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.
  • Balzarro M; Department of Urology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.
  • Rubilotta E; Department of Urology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.
  • Autorino R; Department of Urology, Rush University, Chicago, Illinois, USA.
  • Bertolo R; Department of Urology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.
  • Veccia A; Department of Urology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.
  • Antonelli A; Department of Urology, Azienda Ospedaliera Universitaria Integrata, University of Verona, Verona, Italy.
J Endourol ; 2024 Aug 28.
Article en En | MEDLINE | ID: mdl-39135470
ABSTRACT

Background:

To report the surgical and functional outcomes of the holmium laser enucleation of the prostate (HoLEP) surgical program implemented at a high-volume tertiary referral center and to estimate the learning curve (LC) duration for this surgical procedure.

Methods:

Data of all consecutive patients undergoing HoLEP at the University of Verona between June 2022 and April 2024 were retrieved from a prospectively maintained institutional database of patients undergoing benign prostatic hyperplasia (BPH) surgical treatment. The primary endpoint was functional outcomes evaluation during the surgeons' LC. The secondary endpoint was to define the surgical LC for HoLEP. A multivariable test of means was performed to compare functional outcomes at different time points. After adjusting for potential confounders (age, preoperative pharmacotherapy, and prostate volume), multivariable linear regression models were fitted to evaluate the effect of experience on operative time (OT) and enucleation efficiency. To assess LCs for HoLEP surgery, the non-risk-adjusted cumulative sum (CUSUM) method was used.

Results:

A statistically significant improvement in International Prostate Symptoms Score (IPSS) score, delta% IPSS score, IPSS quality of life (IPSS-QoL) score, and delta% IPSS-QoL score was observed over the study period. Furthermore, the incidence of irritative symptoms (p < 0.001) and stress incontinence (p = 0.01) significantly decreased over time, with a 12-month incidence of 8.4% and 9.5%, respectively. A statistically significant association between experience and both OT and enucleation efficiency was observed in multivariable linear regression analysis. The CUSUM chart for OT and enucleation efficiency showed a steep initial upward/downward trend of ∼50 cases each, and a plateau until ∼100 procedures are reached, where the breakpoint is recognized for both variables and where the CUSUM curve goes below the locally weighted scatterplot smoothing curve in the corresponding observed-expected CUSUM plot.

Conclusions:

HoLEP represents an effective treatment for BPH, demonstrating significant improvement in BPH-related symptoms over the study period, despite the considerable LC of ∼50 cases associated with the procedure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Endourol Asunto de la revista: UROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Endourol Asunto de la revista: UROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos