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Comparison of lipidome profiles in serum from lactating dairy cows supplemented with Acremonium terrestris culture based on UPLC-QTRAP-MS/MS.
Zhang, Chenmiao; Zhao, Yiran; Guo, Shijiao; Li, Feifei; Gong, Xu; Gao, Jiarui; Jiang, Linshu; Tong, Jinjin.
Afiliación
  • Zhang C; Animal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, P. R. China.
  • Zhao Y; Animal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, P. R. China.
  • Guo S; Animal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, P. R. China.
  • Li F; Animal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, P. R. China.
  • Gong X; Animal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, P. R. China.
  • Gao J; Animal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, P. R. China.
  • Jiang L; Animal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, P. R. China.
  • Tong J; Animal Science and Technology College, Beijing University of Agriculture, Beijing, 102206, P. R. China. tongjinjin0451@163.com.
BMC Biotechnol ; 24(1): 56, 2024 Aug 12.
Article en En | MEDLINE | ID: mdl-39135176
ABSTRACT
This study evaluated the effects of supplementing the diet of lactating cows with Acremonium terrestris culture (ATC) on milk production, serum antioxidant capacity, inflammatory indices, and serum lipid metabolomics. Over 90 days, 24 multiparous Chinese Holstein cows in mid-lactation (108 ± 10.4 days in milk, 637 ± 25 kg body weight, 30.23 ± 3.7 kg/d milk yield) were divided into either a control diet (CON) or a diet supplemented with 30 g of ATC daily. All the data were analyzed using Student's t test with SPSS 20.0 software. The results showed that compared with CON feeding, ATC feeding significantly increased milk yield, antioxidant capacity, and immune function. Lipidome screening identified 143 lipid metabolites that differed between the two groups. Further analysis using "random forest" machine learning revealed three glycerophospholipid serum metabolites that could serve as lipid markers with a predictive accuracy of 91.67%. This study suggests that ATC can be a useful dietary supplement for improving lactational performance in dairy cows and provides valuable insights into developing nutritional strategies to maintain metabolic homeostasis in ruminants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acremonium / Lactancia / Suplementos Dietéticos / Espectrometría de Masas en Tándem / Lipidómica Límite: Animals Idioma: En Revista: BMC Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acremonium / Lactancia / Suplementos Dietéticos / Espectrometría de Masas en Tándem / Lipidómica Límite: Animals Idioma: En Revista: BMC Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido