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Causality between migraine and cardiovascular disease: a bidirectional Mendelian randomization study.
Duan, Xirui; Du, Xiaolan; Zheng, Guangrong; Zhou, Xinyan; Tan, Na; Li, Guochen; Liu, Bin; Zhu, Mei; Ke, Tengfei; Liao, Chengde.
Afiliación
  • Duan X; Department of Radiology, Yan'an Hospital of Kunming City (Yan'an Hospital, Kunming Medical University, Yunnan Cardiovascular Hospital), Kunming, China.
  • Du X; Department of Radiology, Yan'an Hospital of Kunming City (Yan'an Hospital, Kunming Medical University, Yunnan Cardiovascular Hospital), Kunming, China.
  • Zheng G; Department of Radiology, Yan'an Hospital of Kunming City (Yan'an Hospital, Kunming Medical University, Yunnan Cardiovascular Hospital), Kunming, China.
  • Zhou X; Department of Radiology, Yan'an Hospital of Kunming City (Yan'an Hospital, Kunming Medical University, Yunnan Cardiovascular Hospital), Kunming, China.
  • Tan N; Department of Radiology, Yan'an Hospital of Kunming City (Yan'an Hospital, Kunming Medical University, Yunnan Cardiovascular Hospital), Kunming, China.
  • Li G; Department of Radiology, Yan'an Hospital of Kunming City (Yan'an Hospital, Kunming Medical University, Yunnan Cardiovascular Hospital), Kunming, China.
  • Liu B; Department of Radiology, Yan'an Hospital of Kunming City (Yan'an Hospital, Kunming Medical University, Yunnan Cardiovascular Hospital), Kunming, China.
  • Zhu M; Department of General Practice, The Third People's Hospital of Yunnan Province, Kunming, China.
  • Ke T; Department of Radiology, Yunnan Cancer Hospital/Center, Third Affiliated Hospital of Kunming Medical University, Kunming, China. 250169995@qq.com.
  • Liao C; Department of Radiology, Yan'an Hospital of Kunming City (Yan'an Hospital, Kunming Medical University, Yunnan Cardiovascular Hospital), Kunming, China. chengdeliao@qq.com.
J Headache Pain ; 25(1): 130, 2024 Aug 13.
Article en En | MEDLINE | ID: mdl-39135164
ABSTRACT

BACKGROUND:

While growing evidence suggests a relationship between migraine and cardiovascular disease, the genetic evidence for a causal relationship between migraine and cardiovascular disease is still scarce. Investigating the causal association between migraine and cardiovascular disease is vital.

METHODS:

We carried out a bidirectional Mendelian randomization (MR) study including discovery samples and replication samples using publicly available genome-wide association study (GWAS) summary datasets and stringent screening instrumental variables. Four different MR techniques-Inverse variance weighted (IVW), MR ‒Egger, weighted median, and weighted mode-as well as various sensitivity analyses-Cochran's Q, IVW radial, leave-one-out (LOO), and MR-PRESSO-were utilized to investigate the causal relationship between cardiovascular disease and migraine.

RESULTS:

The protective causal effects of genetically predicted migraine on coronary artery disease (OR, 0.881; 95% CI 0.790-0.982; p = 0.023) and ischemic stroke (OR, 0.912; 95% CI 0.854-0.974; p = 0.006) were detected in forward MR analysis but not in any other cardiovascular disease. Consistently, we also discovered protective causal effects of coronary atherosclerosis (OR, 0.865; 95% CI 0.797-0.940; p = 0.001) and myocardial infarction (OR, 0.798; 95% CI 0.668-0.952; p = 0.012) on migraine in reverse MR analysis.

CONCLUSION:

We found a potential protective effect of migraine on coronary artery disease and ischemic stroke and a potential protective effect of coronary atherosclerosis and myocardial infarction on migraine. We emphasised epidemiological and genetic differences and the need for long-term safety monitoring of migraine medications and future research to improve cardiovascular outcomes in migraine patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana / Trastornos Migrañosos Límite: Humans Idioma: En Revista: J Headache Pain Asunto de la revista: MEDICINA INTERNA / NEUROLOGIA / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana / Trastornos Migrañosos Límite: Humans Idioma: En Revista: J Headache Pain Asunto de la revista: MEDICINA INTERNA / NEUROLOGIA / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido