Comparison of Metabolic Changes after 6 Months of High-Carbohydrate Diet or High-Fat Diet with Low Dose Streptozotocin Injection in Rats.
Bull Exp Biol Med
; 177(3): 395-400, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-39134815
ABSTRACT
We compared 2 models of metabolic syndrome in rats high-fat diet (58% calories) with single streptozotocin injection at a dose of 25 mg/kg and replacement of water with 20% fructose solution. The model with fructose solution did not cause the main signs of metabolic syndrome over 24 weeks concentrations of glucose, triglycerides, cholesterol, weight, and BP did not significantly differ from the control group (standard diet). At the same time, single streptozotocin administration was followed by the development of persistent hyperglycemia, hypertriglyceridemia, hypercholesterolemia, and signs of visceral obesity. High-fat diet combined with injection of streptozotocin in a low dose can be considered a more representative model of metabolic syndrome in humans.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Triglicéridos
/
Glucemia
/
Estreptozocina
/
Síndrome Metabólico
/
Dieta Alta en Grasa
Límite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2024
Tipo del documento:
Article
País de afiliación:
Rusia
Pais de publicación:
Estados Unidos