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Gut microbiome perturbation and its correlation with tylosin pharmacokinetics in healthy and infected pigs.
Lee, Eon-Bee; Lee, Ga-Yeong; Hossain, Md Akil; Awji, Elias Gebru; Park, Seung-Chun.
Afiliación
  • Lee EB; Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics, Institute for Veterinary Biomedical Science, College of Veterinary Medicine, Kyungpook National University, Daegu, 41566, Republic of Korea.
  • Lee GY; Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics, Institute for Veterinary Biomedical Science, College of Veterinary Medicine, Kyungpook National University, Daegu, 41566, Republic of Korea.
  • Hossain MA; Institute for Tuberculosis Research, College of Pharmacy, University of Illinois Chicago, 833 S Wood St, Chicago, IL, 60612, USA.
  • Awji EG; Independent Researcher, 263 Congressional Ln, Rockville, MD, 20852, USA.
  • Park SC; Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics, Institute for Veterinary Biomedical Science, College of Veterinary Medicine, Kyungpook National University, Daegu, 41566, Republic of Korea. parksch@knu.ac.kr.
Sci Rep ; 14(1): 18670, 2024 08 12.
Article en En | MEDLINE | ID: mdl-39134586
ABSTRACT
Tylosin, an antibiotic with a long history in treating respiratory bacterial infections, has unknown effects on the gut microbiota of healthy and infected pigs. The study aimed to investigate the effect of a therapeutic dose of tylosin on swine gut microbiota and explored the relationship between this effect and tylosin pharmacokinetics (PK). We also assessed whether changes in gut microbiota after tylosin administration differ between healthy animals (n = 7) and animals intranasally co-infected (n = 7) with Actinobacillus pleuropneumoniae and Pasteurella multocida. Both groups were intramuscularly administered with tylosin (20 mg/kg). The 16S rRNA gene analyses revealed a significantly lower species richness and diversity, after tylosin treatment, in the infected than the healthy pigs, with infected pigs having lower levels of Bacteroidetes and Firmicutes and higher levels of Proteobacteria. Greater tylosin exposure (greater area under curve (AUC) and maximum plasma concentration (Cmax), and slower elimination (longer terminal half-life, T1/2) were observed in healthy than infected pigs. Relative abundance of Lactobacillus, Oscillibacter, Prevotella, and Sporobacter was positively and significantly correlated with AUC and Cmax, whereas the abundance of Acinetobacter, Alishewanella, and Pseudomonas was positively and significantly correlated with T1/2 and mean residence time (MRT) of tylosin. Our findings, for the first time, demonstrated significant changes in swine gut microbiota after a single therapeutic dose of tylosin was administered, whereas the effect of these changes on tylosin PK was not evident.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tilosina / Microbioma Gastrointestinal / Antibacterianos Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tilosina / Microbioma Gastrointestinal / Antibacterianos Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido