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Plasma homocysteine and longitudinal change in cognitive function among urban adults.
Beydoun, May A; Beydoun, Hind A; Georgescu, Michael F; Maino Vieytes, Christian A; Fanelli-Kuczmarski, Marie T; Noren Hooten, Nicole; Evans, Michele K; Zonderman, Alan B.
Afiliación
  • Beydoun MA; Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.
  • Beydoun HA; VA National Center on Homelessness Among Veterans, U.S. Department of Veterans Affairs, Washington, DC 20420, USA; Department of Management, Policy, and Community Health, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Georgescu MF; Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.
  • Maino Vieytes CA; Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.
  • Fanelli-Kuczmarski MT; Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.
  • Noren Hooten N; Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.
  • Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.
  • Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.
J Affect Disord ; 364: 65-79, 2024 Nov 01.
Article en En | MEDLINE | ID: mdl-39134149
ABSTRACT

BACKGROUND:

Cross-sectional and longitudinal studies have inconsistently linked cognitive performance and change over time to an elevated level of homocysteine (Hcy), with few conducted among urban adults.

METHODS:

Longitudinal data [Visit 1 (2004-2009) and Visit 2 (2009-2013)] were analyzed from up to 1430 selected Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) participants. Baseline and follow-up blood Hcy was measured, while 11 cognitive function test scores were assessed at either of these two visits. Overall, sex- and race-stratified associations were evaluated using mixed-effects linear regression models, adjusting for key potential confounders. Interaction effects between Hcy and serum levels of folate and vitamin B-12 were also tested.

RESULTS:

We found that greater LnHcyv1 was significantly associated with poorer baseline attention based on higher Loge (TRAILS A, in seconds) [ß (SE) 0.101 (0.031), P = 0.001]. Heterogeneity was also found by sex and by race. Most notably, among men only, LnHcyv1 was associated with faster decline on the BVRT (# of errors), a measure of visuo-spatial memory (ß (SE) 0.297(0.115), P = 0.010, reduced model); while among African American adults only, an elevated and increasing LnHcy over time was associated with faster rate of decline on Loge (TRAILS B, in seconds) [ß (SE) +0.012 (0.005), p = 0.008], a measure of executive function. Interactions between Hcy, folate and vitamin B-12 blood exposures were also detected.

CONCLUSIONS:

In summary, sex- and race-specific adverse association between elevated Hcy and cognitive performance over time were detected among middle-aged urban adults, in domains of attention, visuo-spatial memory and executive functioning.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Población Urbana / Vitamina B 12 / Cognición / Ácido Fólico / Homocisteína Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Población Urbana / Vitamina B 12 / Cognición / Ácido Fólico / Homocisteína Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Affect Disord Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos