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IL10 and CXCL10 mRNA expression in food protein-induced enterocolitis syndrome.
Galliano, Ilaria; Montanari, Paola; Monti, Giovanna; Dini, Maddalena; Calvi, Cristina; Clemente, Anna; Pau, Anna; Gambarino, Stefano; Bergallo, Massimiliano.
Afiliación
  • Galliano I; Department of Pediatric Sciences and Public Health, University of Turin, Piazza Polonia 94, Turin, Italy. Electronic address: ilaria.galliano@unito.it.
  • Montanari P; Department of Pediatric Sciences and Public Health, University of Turin, Piazza Polonia 94, Turin, Italy. Electronic address: paola.montanari@unito.it.
  • Monti G; Pediatric Allergy Unit, Regina Margherita Children's Hospital, Piazza Polonia 94, Turin, Italy. Electronic address: giovanna.monti@email.it.
  • Dini M; Department of Pediatric Sciences and Public Health, University of Turin, Piazza Polonia 94, Turin, Italy. Electronic address: maddalena.dini@unito.it.
  • Calvi C; Department of Pediatric Sciences and Public Health, University of Turin, Piazza Polonia 94, Turin, Italy. Electronic address: cristina.calvi@unito.it.
  • Clemente A; Department of Pediatric Sciences and Public Health, University of Turin, Piazza Polonia 94, Turin, Italy. Electronic address: anna.clemente@unito.it.
  • Pau A; Department of Pediatric Sciences and Public Health, University of Turin, Piazza Polonia 94, Turin, Italy. Electronic address: anna.pau@unito.it.
  • Gambarino S; Department of Pediatric Sciences and Public Health, University of Turin, Piazza Polonia 94, Turin, Italy. Electronic address: gambarino.stefano@gmail.com.
  • Bergallo M; Department of Pediatric Sciences and Public Health, University of Turin, Piazza Polonia 94, Turin, Italy. Electronic address: massimiliano.bergallo@unito.it.
Cytokine ; 182: 156720, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39133968
ABSTRACT

BACKGROUND:

Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE-mediated food allergy that mainly impacts babies and 7toddlers. The exact mechanism of FPIES is not completely understood. By studying the expression of IL-10 and CXCL10 in pediatric FPIES patients, researchers can gain insights into the immune mechanisms underlying this disorder.

METHODS:

Peripheral venous blood was collected and subsequently stabilized with RNA pro. Total RNA was extracted and mRNA levels of CXCL10 and IL-10 was determined with real time PCR.

RESULTS:

Children with FPIES had significantly higher values than the healthy control group (HC) for CXCL10 while FPIES had a significant lower values than the control group for IL-10.

CONCLUSIONS:

Our results show a high production of CXCL10 and a concomitant reduced production of IL-10 in FPIES subjects who have not yet reached tolerance. These data may represent a molecular diagnostic marker for FPIES.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Interleucina-10 / Enterocolitis / Quimiocina CXCL10 / Hipersensibilidad a los Alimentos Límite: Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ARN Mensajero / Interleucina-10 / Enterocolitis / Quimiocina CXCL10 / Hipersensibilidad a los Alimentos Límite: Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido