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Assessment of metabolic and hemostatic profile of apheresis platelet concentrates: does the storage medium play a role?
Petrou, Eleni; Tsalas, Stavros; Tsantes, Andreas G; Loukopoulou, Electra; Mellou, Sofia; Fortis, Sotirios P; Rapti, Evdoxia; Sokou, Rozeta; Kyriakou, Elias; Douramani, Panagiota; Frantzeskaki, Frantzeska; Samonis, George; Kokoris, Styliani; Kriebardis, Anastasios; Tsantes, Argirios E.
Afiliación
  • Petrou E; Laboratory of Hematology and Blood Bank Unit, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  • Tsalas S; Laboratory of Hematology and Blood Bank Unit, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  • Tsantes AG; Laboratory of Hematology and Blood Bank Unit, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  • Loukopoulou E; Laboratory of Hematology and Blood Bank Unit, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  • Mellou S; Transfusion Department, General Hospital of Athens "G. Gennimatas", Athens, Greece.
  • Fortis SP; Laboratory of Reliability and Quality Control in Laboratory Hematology, Department of Biomedical Science, School of Health and Caring Science, University of West Attica, Athens, Greece.
  • Rapti E; Laboratory of Hematology and Blood Bank Unit, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  • Sokou R; Neonatal Intensive Care Unit, "Agios Panteleimon" General Hospital of Nikea, Nikea, Piraeus, Greece.
  • Kyriakou E; Laboratory of Hematology and Blood Bank Unit, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  • Douramani P; Laboratory of Hematology and Blood Bank Unit, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  • Frantzeskaki F; 2nd Department of Critical Care Medicine, General University Hospital "Attikon", Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Samonis G; Department of Oncology, Metropolitan Hospital, Athens, Greece.
  • Kokoris S; Department of Medicine, University of Crete, Heraklion, Greece.
  • Kriebardis A; Laboratory of Hematology and Blood Bank Unit, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  • Tsantes AE; Laboratory of Reliability and Quality Control in Laboratory Hematology, Department of Biomedical Science, School of Health and Caring Science, University of West Attica, Athens, Greece.
Blood Transfus ; 2024 Jul 30.
Article en En | MEDLINE | ID: mdl-39133624
ABSTRACT

BACKGROUND:

The impact of pathogen reduction technology (PRT) on metabolic and haemostatic profile of treated platelets remains a subject of debate. Platelets Additive Solutions (PASs) are suggested as more appropriate storage medium compared to plasma. To investigate this in terms of zero heterogeneity PRT-treated and control apheresis platelet concentrates (PCs), collected from the same donors and stored in PAS and plasma respectively, were analyzed. MATERIALS AND

METHODS:

In the first arm of the study six double dose-apheresis PCs were produced, split and stored in plasma, while in the second arm six split double dose-apheresis PCs from the same donors, were produced and stored in PAS. Control and PRT-treated PCs resulted in both arms. Metabolic and haemostatic markers were evaluated in all the examined groups on days 1, 3 and 5.

RESULTS:

A time dependent increased metabolism both in PAS and plasma-stored PCs was evident in PRT-treated PCs. However, the metabolic profile was better preserved in PCs stored in PAS, as higher pH (6.8 vs 6.5, p=0.007) and lower lactate levels (12.6 vs 17.8 mmol/L, p=0.009) were documented in PRT-treated PAS-PCs compared to plasma-PCs, on day 5. A time dependent decreased hemostatic capacity regardless the storage medium was evident in PRT-treated PCs, (PAS-PCs MCF, p=0.004 and plasma-PCs MCF, p=0.007). Similar results were obtained in control PCs.

DISCUSSION:

The use of PAS preserves the metabolic profile of PCs more adequately compared to plasma but has no effect on the haemostatic profile. The clinical relevance of these findings needs further investigation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Blood Transfus Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Italia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Blood Transfus Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Italia