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A combined treatment for self-traumatic chronic skin lesions associated with post-surgical neuropathic pain in a domestic cat: a pharmacological and cold atmospheric plasma approach.
de Moura, Carlos Eduardo Bezerra; Francelino, Luiz Emanuel Campos; da Silva, Guilherme Ramon Vieira; Júnior, Clodomiro Alves; Façanha, Débora Andréa Evangelista; Nunes, Talyta Lins; de Paula, Valéria Veras.
Afiliación
  • de Moura CEB; Departamento de Ciências Animais, Universidade Federal Rural Do Semi-Árido - Ufersa, Av. Francisco Motta, 572, Costa e Silva, Mossoró, RN, Brazil. carlos.moura@ufersa.edu.br.
  • Francelino LEC; Programa de Pós-Graduação em Ciência Animal, Universidade Federal Rural Do Semi-Árido - Ufersa, Av. Francisco Motta, 572, Costa e Silva, Mossoró, RN, Brazil. carlos.moura@ufersa.edu.br.
  • da Silva GRV; Departamento de Ciências Animais, Universidade Federal Rural Do Semi-Árido - Ufersa, Av. Francisco Motta, 572, Costa e Silva, Mossoró, RN, Brazil.
  • Júnior CA; Departamento de Ciências Animais, Universidade Federal Rural Do Semi-Árido - Ufersa, Av. Francisco Motta, 572, Costa e Silva, Mossoró, RN, Brazil.
  • Façanha DAE; Programa de Pós-Graduação em Ciência e Engenharia de Materiais, Universidade Federal Rural Do Semi-Árido - Ufersa, Av. Francisco Motta, 572, Costa e Silva, Mossoró, RN, Brazil.
  • Nunes TL; Programa de Pós-Graduação em Ciência Animal, Universidade Federal Rural Do Semi-Árido - Ufersa, Av. Francisco Motta, 572, Costa e Silva, Mossoró, RN, Brazil.
  • de Paula VV; Instituto de Desenvolvimento Rural, Universidade da Integração Internacional da Lusofonia Afro-Brasileira - Unilab, Rua José Franco de Oliveira, s/n, Redenção, CE, Brazil.
Vet Res Commun ; 2024 Aug 12.
Article en En | MEDLINE | ID: mdl-39133400
ABSTRACT
Cold atmospheric plasma (CAP) has been employed as a therapy against both acute and chronic skin lesions, contaminated or not, and has effects on angiogenesis and reepithelialization promoting healing. In this context, the present study aimed to evaluate the effects of a CAP jet associated with pharmacological treatment described by the 2015 AAHA/AAFP pain management guidelines and the 2022 WSAVA guidelines for the recognition, assessment, and treatment of pain, on the healing of chronic skin lesions caused by a pruritic reaction resulting from post-surgical neuropathic pain. To this end, a single CAP application was performed on a feline patient with a 6 months old recurrent contaminated cervical skin lesions along with administration of ketamine (10 µg/kg/min) following the prescription of prednisone (1 mg/kg, SID, 6 days), gabapentin (8 mg/kg, BID, 60 days) and amitriptyline (0.5 mg /kg, SID, 60 days). A single application of plasma associated with an NMDA antagonist, anti-inflammatory steroid, tricyclic antidepressant and gabapentinoid thus provided a significant improvement in the macroscopic appearance of the lesion within 10 days, and the owner reported the cessation of intense itching within the first four hours after treatment and a consequent improvement in the animal's quality of life. The medical treatment was finished almost a year since the writing of this paper, without clinical or reported recurrent signs of the condition. Therefore, we observed that single dose CAP application associated with ketamine, gabapentin, amitriptyline and prednisone leads to significant healing of chronically infected skin lesions resulting from post-surgical neuropathic pain.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vet Res Commun Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Vet Res Commun Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza