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Genome Analysis of a Newly Sequenced B. subtilis SRCM117797 and Multiple Public B. subtilis Genomes Unveils Insights into Strain Diversification and Biased Core Gene Distribution.
Abraha, Haftom Baraki; Ramesha, Rathnayaka Mudiyanselage; Ferdiansyah, Mokhammad Khoiron; Son, Hyeonro; Kim, Gayeong; Park, Beomseok; Jeong, Do-Youn; Kim, Kwang-Pyo.
Afiliación
  • Abraha HB; Department of Food Science and Technology, Jeonbuk National University, Jeonju, 54896, South Korea.
  • Ramesha RM; Department of Agricultural Convergence Technology, Jeonbuk National University, Jeonju, 54896, South Korea.
  • Ferdiansyah MK; Department of Food Science and Technology, Jeonbuk National University, Jeonju, 54896, South Korea.
  • Son H; Department of Agricultural Convergence Technology, Jeonbuk National University, Jeonju, 54896, South Korea.
  • Kim G; Department of Food Science and Technology, Jeonbuk National University, Jeonju, 54896, South Korea.
  • Park B; Department of Agricultural Convergence Technology, Jeonbuk National University, Jeonju, 54896, South Korea.
  • Jeong DY; Microbial Institute for Fermentation Industry, Sunchang, 56048, South Korea.
  • Kim KP; Department of Food Science and Technology, Jeonbuk National University, Jeonju, 54896, South Korea. kpkim@jbnu.ac.kr.
Curr Microbiol ; 81(10): 305, 2024 Aug 12.
Article en En | MEDLINE | ID: mdl-39133322
ABSTRACT
The bacterium Bacillus subtilis is a widely used study model and industrial workhorse organism that belongs to the group of gram-positive bacteria. In this study, we report the analysis of a newly sequenced complete genome of B. subtilis strain SRCM117797 along with a comparative genomics of a large collection of B. subtilis strain genomes. B. subtilis strain SRCM117797 has 4,255,638 bp long chromosome with 43.4% GC content and high coding sequence association with macromolecules, metabolism, and phage genes. Genomic diversity analysis of 232 B. subtilis strains resulted in the identification of eight clusters and three singletons. Of 147 B. subtilis strains included, 89.12% had strain-specific genes, of which 6.75% encoded strain-specific insertion sequence family transposases. Our analysis showed a potential role of strain-specific insertion sequence family transposases in intra-cellular accumulation of strain-specific genes. Furthermore, the chromosomal layout of the core genes was biased overrepresented on the upper half (closer to the origin of replication) of the chromosome, which may explain the fast-growing characteristics of B. subtilis. Overall, the study provides a complete genome sequence of B. subtilis strain SRCM117797, show an extensive genomic diversity of B. subtilis strains and insights into strain diversification mechanism and non-random chromosomal layout of core genes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacillus subtilis / Genoma Bacteriano Idioma: En Revista: Curr Microbiol Año: 2024 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacillus subtilis / Genoma Bacteriano Idioma: En Revista: Curr Microbiol Año: 2024 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos