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Sodium fluorescein-guided resection of brain metastases: A needed approach or an option? A systematic review and meta-analysis.
Ohadi, Mohammad Amin Dabbagh; Dashtkoohi, Mohammad; Babaei, Mohammad Reza; Zamani, Raha; Dashtkoohi, Mohadese; Hadjipanayis, Constantinos G.
Afiliación
  • Ohadi MAD; Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Dashtkoohi M; Department of Pediatric Neurological Surgery, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Babaei MR; Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Zamani R; Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Dashtkoohi M; Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Hadjipanayis CG; Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Acta Neurochir (Wien) ; 166(1): 334, 2024 Aug 12.
Article en En | MEDLINE | ID: mdl-39133319
ABSTRACT

PURPOSE:

Brain metastases (BM) often leave residual tumors despite having visible margins, which increases the risk of local tumor recurrence and can impact overall patient survival rates. Fluorescence-guided surgery (FGS) utilizing sodium fluorescein (FL) has been reported as an effective technique in recent studies. This study aimed to evaluate the efficacy of FL FGS in improving the extent of resection of brain metastases and its impact on overall survival.

METHODS:

We conducted a systematic search following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Our primary focus was on gross total resection (GTR). Additionally, we extracted survival data and evaluated the risk of bias using a modified version of the Joanna Briggs Institute critical appraisal tool.

RESULTS:

The study comprised 970 patients with brain metastases through eight different studies. The study found that patients who underwent FL-guided resection had a significantly higher rate of GTR (OR 2.02, 95% CI 1.14-3.56, p = 0.0156, I2 = 41.5%). Additionally, the study concluded that FL-guided resection is associated with better overall survival rates (HR 0.61, 95%CI 0.47 0.80, p = 0.0003, I2 = 41.5%).

CONCLUSION:

Our research suggests that the use of FL is associated with a higher rate of GTR and improved overall patient survival. None of the studies we reviewed reported significant complications associated with the use of FL in patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Fluoresceína Límite: Humans Idioma: En Revista: Acta Neurochir (Wien) Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Austria
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Fluoresceína Límite: Humans Idioma: En Revista: Acta Neurochir (Wien) Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Austria