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The clinical characteristics analysis of serum markers for the cardiovascular system in early-stage COVID-19 patients.
Cao, Xi; Xie, Yong-Li; Yi, Jian-Ying; Liu, Zhi-Li; Zhang, Dong-Dong; Yue, Ying-Ying; Li, Tian-Ning; Zhou, Chun-Lei; Mu, Hong.
Afiliación
  • Cao X; Department of Clinical Laboratory, Tianjin First Central Hospital, Tianjin, China.
  • Xie YL; Department of Clinical Laboratory, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China.
  • Yi JY; Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Stomatological Hospital, Tianjin, China.
  • Liu ZL; Department of Clinical Laboratory, Tianjin First Central Hospital, Tianjin, China.
  • Zhang DD; Department of Clinical Laboratory, The Third Central Hospital, Tianjin, China.
  • Yue YY; Department of Clinical Laboratory, Tianjin First Central Hospital, Tianjin, China.
  • Li TN; Department of Clinical Laboratory, Tianjin First Central Hospital, Tianjin, China.
  • Zhou CL; Department of Clinical Laboratory, Tianjin First Central Hospital, Tianjin, China.
  • Mu H; Department of Clinical Laboratory, Tianjin First Central Hospital, Tianjin, China.
Front Cardiovasc Med ; 11: 1401586, 2024.
Article en En | MEDLINE | ID: mdl-39131705
ABSTRACT

Background:

This study aimed to investigate alterations in serum markers [creatine kinase-MB (CKMB), cardiac troponin T (cTnT), myoglobin (Myo), B-type natriuretic peptide (BNP), D-dimer (DD), procalcitonin (PCT) and interleukin-6 (IL6)] in early Omicron variant infection and analyzed their correlation with clinical parameters.

Methods:

Retrospective analysis of 1,138 mild/asymptomatic cases at Tianjin First Central Hospital, including age, gender, serum markers and nucleic acid test results. Statistical analysis used SPSS software, version 24.0.

Results:

Elevated cTnT, BNP (125-400), and DD (0.55-1.10) levels were prevalent at 12.92%, 15.64%, and 14.50%, respectively. Females had significantly higher proportions with slightly elevated BNP (19.34%) and DD (19.69%) levels. Patients over 35 had a higher proportion of slight elevation in BNP (20.00%). Abnormal levels of serum markers were significantly associated with older age, increased PCT and IL6 levels, as well as delayed nucleic acid clearance. Additionally, levels of immunoglobulin G (IgG) were notably reduced in these cases. Patients with prolonged nucleic acid clearance (>14 days) had higher BNP and DD levels upon admission. Logistic regression identified PCT (OR = 237.95) as the most significant risk factor for abnormal serum markers for cardiovascular system injury.

Conclusion:

Early Omicron infection might do subclinical damage to the cardiovascular system. Elevated cTnT, BNP and DD levels were correlated with age, gender, inflammatory factors, and IgG. Notably, high PCT level emerged as the most robust predictor of abnormal serum biomarkers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cardiovasc Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cardiovasc Med Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza