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Conservation, alteration, and redistribution of mammalian striatal interneurons.
Corrigan, Emily K; DeBerardine, Michael; Poddar, Aunoy; Turrero García, Miguel; Schmitz, Matthew T; Harwell, Corey C; Paredes, Mercedes F; Krienen, Fenna M; Pollen, Alex A.
Afiliación
  • Corrigan EK; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
  • DeBerardine M; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Poddar A; Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
  • Turrero García M; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
  • Schmitz MT; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Harwell CC; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
  • Paredes MF; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
  • Krienen FM; Allen Institute for Brain Science, Seattle, WA, USA.
  • Pollen AA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.
bioRxiv ; 2024 Jul 29.
Article en En | MEDLINE | ID: mdl-39131311
ABSTRACT
Mammalian brains vary in size, structure, and function, but the extent to which evolutionarily novel cell types contribute to this variation remains unresolved1-4. Recent studies suggest there is a primate-specific population of striatal inhibitory interneurons, the TAC3 interneurons5. However, there has not yet been a detailed analysis of the spatial and phylogenetic distribution of this population. Here, we profile single cell gene expression in the developing pig (an ungulate) and ferret (a carnivore), representing 94 million years divergence from primates, and assign newborn inhibitory neurons to initial classes first specified during development6. We find that the initial class of TAC3 interneurons represents an ancestral striatal population that is also deployed towards the cortex in pig and ferret. In adult mouse, we uncover a rare population expressing Tac2, the ortholog of TAC3, in ventromedial striatum, prompting a reexamination of developing mouse striatal interneuron initial classes by targeted enrichment of their precursors. We conclude that the TAC3 interneuron initial class is conserved across Boreoeutherian mammals, with the mouse population representing Th striatal interneurons, a subset of which expresses Tac2. This study suggests that initial classes of telencephalic inhibitory neurons are largely conserved and that during evolution, neuronal types in the mammalian brain change through redistribution and fate refinement, rather than by derivation of novel precursors early in development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: BioRxiv Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos