Your browser doesn't support javascript.
loading
Clinical and Imaging Predictors of Pancreatic Cancer in Patients Hospitalized for Acute Pancreatitis.
Luong, Tiffany Q; Chen, Qiaoling; Tran, Tri M; Zhou, Yichen; Lustigova, Eva; Chen, Wansu; Wu, Bechien U.
Afiliación
  • Luong TQ; Department of Research & Evaluation, Southern California Permanente Medical Group, Pasadena, California.
  • Chen Q; Department of Research & Evaluation, Southern California Permanente Medical Group, Pasadena, California.
  • Tran TM; Department of Internal Medicine, Southern California Permanente Medical Group, Los Angeles, California.
  • Zhou Y; Department of Research & Evaluation, Southern California Permanente Medical Group, Pasadena, California.
  • Lustigova E; Department of Research & Evaluation, Southern California Permanente Medical Group, Pasadena, California.
  • Chen W; Department of Research & Evaluation, Southern California Permanente Medical Group, Pasadena, California.
  • Wu BU; Department of Gastroenterology, Southern California Permanente Medical Group, Los Angeles, California.
Gastro Hep Adv ; 1(6): 1027-1036, 2022.
Article en En | MEDLINE | ID: mdl-39131243
ABSTRACT
Background and

Aims:

Identifying factors associated with increased short-term risk of pancreatic cancer in the setting of acute pancreatitis (AP) can inform clinical care decisions and expedite cancer diagnosis.

Methods:

A retrospective cohort study of patients hospitalized for AP between 2007 and 2017 in an integrated health-care system in Southern California. AP cases were identified by diagnosis code with laboratory confirmation. Multivariable Cox proportional hazards regression model was used to assess risk of pancreatic cancer within 3 years of AP, adjusting for patient demographics, clinical parameters (body mass index, AP etiology, chronic pancreatitis, diabetes) and radiographic imaging features.

Results:

Among 9,490 patients hospitalized with AP, the mean (standard deviation) age was 55.8 (17.8) years, 55% were women, and 42% were Hispanic. Majority of AP cases were biliary (64%), 12% were alcohol-related, 5% were hypertriglyceridemia-induced, and 19% were other/unknown etiology. Ninety-five (1%) patients were diagnosed with pancreatic cancer within 3 years of AP (4.2 cases/1000 person-years). Risk factors for pancreatic cancer were age ≥65 years (hazard risk [HR] 2.5, 95% confidence interval [CI] 1.2-5.3), male sex (HR 1.9, 95% CI 1.2-2.8), Asian/Pacific Islander race (HR 2.0, 95% CI 1.1-3.6), and underweight body mass index (HR 2.6, 95% CI 1.1-6.5). In addition, other/unknown AP etiology (HR 2.0, 95% CI 1.3-3.1) and dilatation of the main pancreatic duct (HR 6.6, 95% CI 4.2-10.5) were independently associated with increased risk of pancreatic cancer.

Conclusion:

In addition to older age, the lack of well-established etiology, underweight body habitus, and main pancreatic duct dilatation were independently associated with increased short-term risk of pancreatic cancer among patients hospitalized for AP.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Gastro Hep Adv Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Gastro Hep Adv Año: 2022 Tipo del documento: Article Pais de publicación: Países Bajos