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Efficacy of Coronary Calcium Score in Predicting Coronary Artery Morphology in Patients With Obstructive Coronary Artery Disease.
He, Xingwei; Maung, Soe; Ramasamy, Anantharaman; Mohamed, Mohamed O; Bajaj, Retesh; Yap, Nathan Angelo Lecaros; Karaduman, Medeni; Zhang, Yaojun; Kitslaar, Pieter; Broersen, Alexander; Reiber, Johan H C; Dijkstra, Jouke; Serruys, Patrick W; Moon, James C; Baumbach, Andreas; Torii, Ryo; Pugliese, Francesca; Bourantas, Christos V.
Afiliación
  • He X; Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom.
  • Maung S; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Ramasamy A; Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom.
  • Mohamed MO; Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom.
  • Bajaj R; Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
  • Yap NAL; Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom.
  • Karaduman M; Institute of Health Informatics, University College London, London, United Kingdom.
  • Zhang Y; Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom.
  • Kitslaar P; Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
  • Broersen A; Department of Cardiology, Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom.
  • Reiber JHC; Department of Cardiology, Faculty of Medicine, Yuzuncu Yil University Van, Van, Turkey.
  • Dijkstra J; Department of Cardiology, Xuzhou Third People's Hospital, Xuzhou, China.
  • Serruys PW; Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Moon JC; Medis Medical Imaging Systems, Leiden, the Netherlands.
  • Baumbach A; Medis Medical Imaging Systems, Leiden, the Netherlands.
  • Torii R; Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Pugliese F; Medis Medical Imaging Systems, Leiden, the Netherlands.
  • Bourantas CV; Medis Medical Imaging Systems, Leiden, the Netherlands.
J Soc Cardiovasc Angiogr Interv ; 3(3Part B): 101308, 2024 Mar.
Article en En | MEDLINE | ID: mdl-39131224
ABSTRACT

Background:

Coronary artery calcium score (CACS) is an established marker of coronary artery disease (CAD) and has been extensively used to stratify risk in asymptomatic individuals. However, the value of CACS in predicting plaque morphology in patients with advanced CAD is less established. The present analysis aims to assess the association between CACS and plaque characteristics detected by near-infrared spectroscopy-intravascular ultrasound (NIRS-IVUS) imaging in patients with obstructive CAD.

Methods:

Seventy patients with obstructive CAD underwent coronary computed tomography angiography (CTA) and 3-vessel NIRS-IVUS imaging were included in the present analysis. The CTA data were used to measure the CACS in the entire coronary tree and the segments assessed by NIRS-IVUS, and these estimations were associated with the NIRS-IVUS measurements at a patient and segment level.

Results:

In total, 65 patients (188 segments) completed the study protocol and were included in the analysis. A weak correlation was noted between the CACS, percent atheroma volume (r = 0.271, P = .002), and the calcific burden measured by NIRS-IVUS (r = 0.648, P < .001) at patient-level analysis. Conversely, there was no association between the CACS and the lipid content, or the incidence of high-risk plaques detected by NIRS. Linear regression analysis at the segment level demonstrated an association between the CACS and the total atheroma volume (coefficient, 0.087; 95% CI, 0.024-0.149; P = .008) and the calcific burden (coefficient, 0.117; 95% CI, 0.048-0.186; P = .001), but there was no association between the lipid content or the incidence of high-risk lesions.

Conclusions:

In patients with obstructive CAD, the CACS is not associated with the lipid content or plaque phenotypes. These findings indicate that the CACS may have a limited value for screening or stratifying cardiovascular risk in symptomatic patients with a high probability of CAD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Soc Cardiovasc Angiogr Interv Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Soc Cardiovasc Angiogr Interv Año: 2024 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos