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Global Prevalence, Risk Factors, and Outcomes of Depression After Liver Transplant: A Systematic Review and Meta-analysis.
Lim, Wen Hui; Poh, Chen Wei; Tan, Beatrice Jia Min; Ng, Cheng Han; Tan, Darren Jun Hao; Lim, Xiong Chang; Tay, Phoebe Wen Lin; Lim, Grace En Hui; Huang, Daniel Q; Ho, Cyrus S H; Tan, Eunice Xiang-Xuan; Syn, Nicholas; Dan, Yock Young; Griva, Konstadina; Fung, James; Siddiqui, Mohammad Shadab; Muthiah, Mark Dhinesh.
Afiliación
  • Lim WH; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Poh CW; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Tan BJM; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Ng CH; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Tan DJH; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Lim XC; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Tay PWL; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Lim GEH; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Huang DQ; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Ho CSH; National University Centre for Organ Transplantation, National University Health System, Singapore.
  • Tan EX; Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore.
  • Syn N; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Dan YY; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Griva K; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
  • Fung J; National University Centre for Organ Transplantation, National University Health System, Singapore.
  • Siddiqui MS; Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore, Singapore.
  • Muthiah MD; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Gastro Hep Adv ; 1(2): 150-159, 2022.
Article en En | MEDLINE | ID: mdl-39131130
ABSTRACT
Background and

aims:

With existing literature focusing on general quality of life, the magnitude and impact of depression among recipients after liver transplantation (LT) is unclear. Hence, we aim to evaluate the prevalence, risk factors, and outcomes for recipient-related depression after LT.

Methods:

Medline and Embase were searched. Single-arm analysis was pooled using the generalized linear mixed model, and logistic regression was performed to analyze risk factors. Pairwise comparative meta-analysis in odds ratio was conducted for binary outcomes.

Results:

Of 1069 abstracts, 189 articles underwent full-text review before the inclusion of 48 articles. Pooled depression rate among 5170 recipients was 24.52% (confidence interval [CI] 19.46%-30.41%). Depression was most prevalent in Asia compared with other geographical regions. Younger age at transplantation (P = .019) and university education (P = .051) were protective against depression. However, those transplanted for alcoholic liver disease (odds ratio 1.14, CI 1.10-1.18, P ≤ 0.001) were more likely to be depressed. Depression resulted in increased odds of mortality (odds ratio 1.82, CI 1.08-3.07, P = .04), graft loss (P = .03), and graft rejection (P = .01).

Conclusion:

Depression is highly prevalent after LT and may be associated with increased mortality and poorer graft outcomes. More emphasis is needed on the screening of depression among higher risk recipients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Gastro Hep Adv Año: 2022 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Gastro Hep Adv Año: 2022 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Países Bajos