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Mechanism of mitochondrial [2Fe-2S] cluster biosynthesis.
Want, Kristian; D'Autréaux, Benoit.
Afiliación
  • Want K; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.
  • D'Autréaux B; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France. Electronic address: benoit.dautreaux@i2bc.paris-saclay.fr.
Biochim Biophys Acta Mol Cell Res ; 1871(8): 119811, 2024 Aug 10.
Article en En | MEDLINE | ID: mdl-39128597
ABSTRACT
Iron­sulfur (Fe-S) clusters constitute ancient cofactors that accompany a versatile range of fundamental biological reactions across eukaryotes and prokaryotes. Several cellular pathways exist to coordinate iron acquisition and sulfur mobilization towards a scaffold protein during the tightly regulated synthesis of Fe-S clusters. The mechanism of mitochondrial eukaryotic [2Fe-2S] cluster synthesis is coordinated by the Iron-Sulfur Cluster (ISC) machinery and its aberrations herein have strong implications to the field of disease and medicine which is therefore of particular interest. Here, we describe our current knowledge on the step-by-step mechanism leading to the production of mitochondrial [2Fe-2S] clusters while highlighting the recent developments in the field alongside the challenges that are yet to be overcome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biochim Biophys Acta Mol Cell Res Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biochim Biophys Acta Mol Cell Res Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Países Bajos