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Linderangolides A-D, four new butanolides from the roots of Lindera angustifolia and their cytotoxic activity.
Wei, Jieqin; Guo, Jiaqi; Shi, Qi; Wang, Yiwen; Zhou, Manjia; Ren, Hangjie; Ma, Runchao; Ying, Jiani; Meng, Xiongyu; Qin, Lupin; Li, Huaqiang.
Afiliación
  • Wei J; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Baichuan Street 260, Hangzhou 311403, China.
  • Guo J; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Baichuan Street 260, Hangzhou 311403, China.
  • Shi Q; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Baichuan Street 260, Hangzhou 311403, China.
  • Wang Y; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Baichuan Street 260, Hangzhou 311403, China.
  • Zhou M; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Baichuan Street 260, Hangzhou 311403, China.
  • Ren H; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Baichuan Street 260, Hangzhou 311403, China.
  • Ma R; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Baichuan Street 260, Hangzhou 311403, China.
  • Ying J; The Medical Research Center, Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Binwen Road 548, Hangzhou 310053, China.
  • Meng X; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Baichuan Street 260, Hangzhou 311403, China. Electronic address: mengxiongyu@zcmu.edu.cn.
  • Qin L; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Baichuan Street 260, Hangzhou 311403, China. Electronic address: lpqin@zcmu.edu.cn.
  • Li H; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Baichuan Street 260, Hangzhou 311403, China. Electronic address: lihq009@zcmu.edu.cn.
Fitoterapia ; 178: 106180, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39128554
ABSTRACT
Four undescribed butanolides, linderangolides A-D (1-4), along with four known congeners, lincomolide A (5), (-)-epilitsenolide C2 (6), (-)-epilitsenolide C1 (7) and litseakolide H (8), were isolated from the roots of Lindera angustifolia. The planar structures of 1-4 were elucidated based on extensive spectroscopic analyses, the relative and absolute configurations of 1-4 were determined by the NOESY spectra and the comparison of calculated and experimental ECD. The cytotoxic activities of all isolated compounds were tested, 4 showed inhibitory activity against SGC-7 cells with IC50 value of 6.62 µM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Raíces de Plantas / Lindera / Fitoquímicos / Antineoplásicos Fitogénicos Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Raíces de Plantas / Lindera / Fitoquímicos / Antineoplásicos Fitogénicos Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos