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Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments.
Quílez, Cristina; Bebiano, Luís B; Jones, Eleri; Maver, Uros; Meesters, Luca; Parzymies, Piotr; Petiot, Emma; Rikken, Gijs; Risueño, Ignacio; Zaidi, Hamza; Zidaric, Tanja; Bekeschus, Sander; H van den Bogaard, Ellen; Caley, Matthew; Colley, Helen; López, Nuria Gago; Letsiou, Sophia; Marquette, Christophe; Maver, Tina; Pereira, Rúben F; Tobin, Desmond J; Velasco, Diego.
Afiliación
  • Quílez C; Bioengineering Department, Universidad Carlos III de Madrid, Leganés, Spain; Fundación Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Madrid, Spain.
  • Bebiano LB; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Porto, Portugal.
  • Jones E; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
  • Maver U; Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia; Department of Pharmacology, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
  • Meesters L; Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Parzymies P; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
  • Petiot E; 3d.FAB, CNRS, INSA, Univ Lyon, CPE-Lyon, UMR5246, ICBMS, Université Lyon 1, Villeurbanne Cedex, France.
  • Rikken G; Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Risueño I; Bioengineering Department, Universidad Carlos III de Madrid, Leganés, Spain; Fundación Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Madrid, Spain.
  • Zaidi H; 3d.FAB, CNRS, INSA, Univ Lyon, CPE-Lyon, UMR5246, ICBMS, Université Lyon 1, Villeurbanne Cedex, France.
  • Zidaric T; Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
  • Bekeschus S; Clinic and Policlinic for Dermatology and Venerology, Rostock University Medical Center, Rostock, Germany; ZIK plasmatis, Leibniz Institute for Plasma Science and Technology (INP Greifswald), Greifswald, Germany.
  • H van den Bogaard E; Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Caley M; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
  • Colley H; School of Clinical Dentistry, University of Sheffield, Sheffield, United Kingdom.
  • López NG; Melanoma group, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
  • Letsiou S; Department of Biomedical Sciences, University of West Attica, Athens, Greece; Department of Food Science and Technology, University of West Attica, Athens, Greece.
  • Marquette C; 3d.FAB, CNRS, INSA, Univ Lyon, CPE-Lyon, UMR5246, ICBMS, Université Lyon 1, Villeurbanne Cedex, France.
  • Maver T; Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia; Department of Pharmacology, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
  • Pereira RF; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Instituto de Engenharia Biomédica (INEB), Universidade do Porto, Porto, Portugal; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
  • Tobin DJ; Charles Institute of Dermatology, University College Dublin, Dublin, Ireland; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
  • Velasco D; Bioengineering Department, Universidad Carlos III de Madrid, Leganés, Spain; Fundación Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz, Madrid, Spain. Electronic address: divelasc@ing.uc3m.es.
J Invest Dermatol ; 2024 Aug 09.
Article en En | MEDLINE | ID: mdl-39127929
ABSTRACT
Skin in vitro models offer much promise for research, testing drugs, cosmetics, and medical devices, reducing animal testing and extensive clinical trials. There are several in vitro approaches to mimicking human skin behavior, ranging from simple cell monolayer to complex organotypic and bioengineered 3-dimensional models. Some have been approved for preclinical studies in cosmetics, pharmaceuticals, and chemicals. However, development of physiologically reliable in vitro human skin models remains in its infancy. This review reports on advances in in vitro complex skin models to study skin homeostasis, aging, and skin disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Invest Dermatol Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Invest Dermatol Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos