Florfenicol induces malformations of embryos and causes altered lipid profile, oxidative damage, neurotoxicity, and histological effects on gonads of adult sea urchin, Paracentrotus lividus.
Environ Toxicol Pharmacol
; 110: 104533, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-39127436
ABSTRACT
The frequent occurrence of antibiotics in the aquatic environment has engendered negative impacts on non-target organisms. The effects of the veterinary antibiotic florfenicol (FLO) during the embryo-larval development of the sea urchin, Paracentrotus lividus was assessed using four increasing concentrations (1, 2, 5 and 10â¯mg/L). Furthermore, FLO toxicity to adults was investigated through the analysis of oxidative damage, histopathological alterations, lipid metabolism and acetylcholinesterase activity following an exposure period of 96â¯h. FLO induced embryotoxicity with estimated EC50 values of 5.75, 7.56 and 3.29â¯mg/L after 12â¯h, 24â¯h and 48â¯h, respectively. It generated oxidative stress assessed as lipid peroxidation in gonads despite the increased antioxidant activity of catalase (CAT). Neurotoxicity was also evident since the AChE activity significantly decreased. Moreover, FLO affected the lipid metabolism by increasing saturated fatty acid (SFA) and monounsaturated fatty acid proportions (MUFA), except in the group exposed to 5â¯mg/L. The increase in polyunsaturated fatty acid (PUFA) levels and docosahexaenoic acid (DHA, C226n-3) proportions were noted with all FLO concentrations. Eicosapentaenoic acid (EPA, C205n-3) decreased, while arachidonic acid (ARA, C204n-6) increased in sea urchins exposed to 5 and 10â¯mg/L FLO. Histopathological alterations of gonadal tissues represent an additional confirmation about the toxicity of this antibiotic that might decrease the reproductive performance of this species. Nevertheless, even if reproduction of sea urchins would be partially successful, the embryotoxicity would compromise the normal development of the embryos with consequences on the population.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tianfenicol
/
Contaminantes Químicos del Agua
/
Estrés Oxidativo
/
Paracentrotus
/
Embrión no Mamífero
/
Gónadas
/
Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
Environ Toxicol Pharmacol
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Países Bajos