Your browser doesn't support javascript.
loading
Florfenicol induces malformations of embryos and causes altered lipid profile, oxidative damage, neurotoxicity, and histological effects on gonads of adult sea urchin, Paracentrotus lividus.
El Ayari, Tahani; Ben Ahmed, Raja; Bouriga, Nawzet; Gravato, Carlos; Chelbi, Emna; Nechi, Salwa; El Menif, Najoua Trigui.
Afiliación
  • El Ayari T; Group of Fundamental and Applied Malacology (MAF), Laboratory of Environment Bio-monitoring (LBE), Faculty of Sciences of Bizerte, University of Carthage, Bizerte, Zarzouna 7021, Tunisia. Electronic address: tahaniayari@yahoo.fr.
  • Ben Ahmed R; University of El Manar, Faculty of Sciences of Tunis, Department of Biology, Ecology, Biology and physiology of Aquatic Organisms Laboratory, Tunis, Tunisia.
  • Bouriga N; University of El Manar, Faculty of Sciences of Tunis, Department of Biology, Ecology, Biology and physiology of Aquatic Organisms Laboratory, Tunis, Tunisia; Higher Institute of Fisheries and Aquaculture of Bizerte, University of Carthage., Errimel B.P.15, Bizerte 7080, Tunisia.
  • Gravato C; Centre for Ecology, Evolution and Environmental Changes (cE3c) & CHANGE - Global Change and Sustainability Institute, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Lisboa 1749-016, Portugal; Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, Campo Gran
  • Chelbi E; Anatomy and Cytology Service, CHU Mohamed Taher Maamouri Hospital, University Tunis El Manar, Tunis 2092, Tunisia.
  • Nechi S; Anatomy and Cytology Service, CHU Mohamed Taher Maamouri Hospital, University Tunis El Manar, Tunis 2092, Tunisia.
  • El Menif NT; Group of Fundamental and Applied Malacology (MAF), Laboratory of Environment Bio-monitoring (LBE), Faculty of Sciences of Bizerte, University of Carthage, Bizerte, Zarzouna 7021, Tunisia.
Environ Toxicol Pharmacol ; 110: 104533, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39127436
ABSTRACT
The frequent occurrence of antibiotics in the aquatic environment has engendered negative impacts on non-target organisms. The effects of the veterinary antibiotic florfenicol (FLO) during the embryo-larval development of the sea urchin, Paracentrotus lividus was assessed using four increasing concentrations (1, 2, 5 and 10 mg/L). Furthermore, FLO toxicity to adults was investigated through the analysis of oxidative damage, histopathological alterations, lipid metabolism and acetylcholinesterase activity following an exposure period of 96 h. FLO induced embryotoxicity with estimated EC50 values of 5.75, 7.56 and 3.29 mg/L after 12 h, 24 h and 48 h, respectively. It generated oxidative stress assessed as lipid peroxidation in gonads despite the increased antioxidant activity of catalase (CAT). Neurotoxicity was also evident since the AChE activity significantly decreased. Moreover, FLO affected the lipid metabolism by increasing saturated fatty acid (SFA) and monounsaturated fatty acid proportions (MUFA), except in the group exposed to 5 mg/L. The increase in polyunsaturated fatty acid (PUFA) levels and docosahexaenoic acid (DHA, C226n-3) proportions were noted with all FLO concentrations. Eicosapentaenoic acid (EPA, C205n-3) decreased, while arachidonic acid (ARA, C204n-6) increased in sea urchins exposed to 5 and 10 mg/L FLO. Histopathological alterations of gonadal tissues represent an additional confirmation about the toxicity of this antibiotic that might decrease the reproductive performance of this species. Nevertheless, even if reproduction of sea urchins would be partially successful, the embryotoxicity would compromise the normal development of the embryos with consequences on the population.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tianfenicol / Contaminantes Químicos del Agua / Estrés Oxidativo / Paracentrotus / Embrión no Mamífero / Gónadas / Antibacterianos Límite: Animals Idioma: En Revista: Environ Toxicol Pharmacol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tianfenicol / Contaminantes Químicos del Agua / Estrés Oxidativo / Paracentrotus / Embrión no Mamífero / Gónadas / Antibacterianos Límite: Animals Idioma: En Revista: Environ Toxicol Pharmacol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos