Embryonic aneuploidy - the true "last barrier in assisted reproductive technology"?

Quaas, Alexander M; Penzias, Alan S; Adashi, Eli Y

Quaas, Alexander M; Penzias, Alan S; Adashi, Eli Y.

Afiliación

Quaas AM; Shady Grove Fertility Center, San Diego, California.
Penzias AS; Boston IVF, Waltham, Massachusetts; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, Massachusetts.
Adashi EY; Department of Medical Science, Warren Alpert Medical School, Brown University, Providence, Rhode Island.

F S Sci ; 2024 Aug 08.

Article en En | MEDLINE | ID: mdl-39127422

ABSTRACT

ABSTRACT

Human embryonic aneuploidy may represent one of the final frontiers in assisted reproductive technology, primarily secondary to oocyte aneuploidy. Mammalian oocytes possess unique characteristics predisposing them to much higher rates of aneuploidy than sperm or most somatic cells. Some of these characteristics are age-independent, whereas others result from reproductive aging and environmental toxicity. A detailed understanding of these properties may lead to novel diagnostic and therapeutic tools designed to detect and prevent oocyte and embryonic aneuploidy to overcome this ultimate barrier to success in assisted reproductive technology.

Palabras clave

Embryonic aneuploidy; assisted reproductive technology (ART); environmental toxins; mammalian oocytes; reproductive aging

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: F S Sci Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos

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