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New potential diagnostic markers for verrucous hyperplasia and verrucous carcinoma based on RNA-sequencing data.
Kim, Janghyun; Kang, Jee-Hye; Noh, Myung-Giun; Lee, Bora; Choi, Yoo-Duk; Kim, Ok Joon; Kim, Young.
Afiliación
  • Kim J; Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju, 61186, Republic of Korea; Hard-Tissue Biointerface Research Center, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea.
  • Kang JH; Deparment of Dental Science, Graduate School, Chonnam National University, Gwangju, 61186, Republic of Korea.
  • Noh MG; Department of Pathology, School of Medicine, Ajou University, Gyeonggi-do, 16499, Republic of Korea.
  • Lee B; Department of Biochemistry, Chonnam National University Medical School, Jeollanam-do, Hwasun 58128, Republic of Korea.
  • Choi YD; Department of Pathology, Chonnam National University Medical School, Gwangju, 61469, Republic of Korea.
  • Kim OJ; Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju, 61186, Republic of Korea.
  • Kim Y; Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju, 61186, Republic of Korea; Hard-Tissue Biointerface Research Center, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea. Electronic address: youngkim2017@jnu.ac.kr.
Mol Cell Probes ; 77: 101980, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39127310
ABSTRACT
Verrucous carcinoma (VC) is a rare subtype of squamous cell carcinoma (SCC) characterized by its histological presentation as a low-grade tumor with no potential for metastasis, setting it apart from invasive SCC. However, distinguishing VC from its benign counterpart, verrucous hyperplasia (VH), is challenging due to their clinical and morphological similarities. Despite the importance of accurate diagnosis for determining treatment strategies, diagnosis of VH and VC relied only on lesion recurrence after resection. To address this challenge, we generated RNA profiling data from tissue samples of VH and VC patients to identify novel diagnostic markers. We analyzed differentially expressed (DE) mRNA and long non-coding RNA (lncRNA) in tissue samples from VH and VC patients. Additionally, ChIP-X Enrichment Analysis 3 (ChEA3) was conducted to identify the top five transcription factors potentially regulating the expression of DE mRNAs in VH and VC. Our analysis of mRNA and lncRNA expression profiles in VH and VC provides insights into the underlying molecular characteristics of these diseases and offers potential new diagnostic markers. The identification of specific DE genes and lncRNAs may enable clinicians to more accurately differentiate between VH and VC, leading to better treatment choices.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Carcinoma Verrugoso / ARN Largo no Codificante / Hiperplasia Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Cell Probes Asunto de la revista: BIOLOGIA MOLECULAR / BIOTECNOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Carcinoma Verrugoso / ARN Largo no Codificante / Hiperplasia Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mol Cell Probes Asunto de la revista: BIOLOGIA MOLECULAR / BIOTECNOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido