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CD31 orchestrates metabolic regulation in autophagy pathways of rheumatoid arthritis.
Cheung, Kenneth Cp; Ma, Jiao; Wang, Lu; Chen, Xingxuan; Fanti, Silvia; Li, Mingzhang; Azevedo, Loiola Rodrigo; Gosselet, Fabien; Shen, Hao; Zheng, Xiaojiao; Lu, Aiping; Jia, Wei.
Afiliación
  • Cheung KC; Phenome Research Center, Hong Kong Baptist University School of Chinese Medicine, Hong Kong, China. Electronic address: kcpcheung@hkbu.edu.hk.
  • Ma J; Phenome Research Center, Hong Kong Baptist University School of Chinese Medicine, Hong Kong, China.
  • Wang L; Phenome Research Center, Hong Kong Baptist University School of Chinese Medicine, Hong Kong, China.
  • Chen X; Phenome Research Center, Hong Kong Baptist University School of Chinese Medicine, Hong Kong, China.
  • Fanti S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
  • Li M; Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
  • Azevedo LR; Faculté de Sciences Jean Perrin, Blood-brain barrier laboratory, Université d'Artois, France.
  • Gosselet F; Faculté de Sciences Jean Perrin, Blood-brain barrier laboratory, Université d'Artois, France.
  • Shen H; Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
  • Zheng X; Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
  • Lu A; Phenome Research Center, Hong Kong Baptist University School of Chinese Medicine, Hong Kong, China.
  • Jia W; Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China; Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China.
Pharmacol Res ; 207: 107346, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39127263
ABSTRACT
Synovitis is characterized by a distinctmetabolic profile featuring the accumulation of lactate, a byproduct of cellular metabolism within inflamed joints. This study reveals that the activation of the CD31 signal by lactate instigates a metabolic shift, specifically initiating endothelial cell autophagy. This adaptive process plays a pivotal role in fulfilling the augmented energy and biomolecule demands associated with the formation of new blood vessels in the synovium of Rheumatoid Arthritis (RA). Additionally, the amino acid substitutions in the CD31 cytoplasmic tail at the Y663F and Y686F sites of the immunoreceptor tyrosine-based inhibitory motifs (ITIM) alleviate RA. Mechanistically, this results in the downregulation of glycolysis and autophagy pathways. These findings significantly advance our understanding of potential therapeutic strategies for modulating these processes in synovitis and, potentially, other autoimmune diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Autofagia / Molécula-1 de Adhesión Celular Endotelial de Plaqueta Límite: Animals / Humans / Male Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Autofagia / Molécula-1 de Adhesión Celular Endotelial de Plaqueta Límite: Animals / Humans / Male Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos