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The burden of pediatric critical illness among pediatric oncology patients in low- and middle-income countries: A systematic review and meta-analysis.
Gabela, Alejandra; Wösten-van Asperen, Roelie M; Arias, Anita V; Acuña, Carlos; Zebin, Zebin Al; Lopez-Baron, Eliana; Bhattacharyya, Parthasarathi; Duncanson, Lauren; Ferreira, Daiane; Gunasekera, Sanjeeva; Hayes, Samantha; McArthur, Jennifer; Nagarajan, Vaishnavi Divya; Puerto Torres, Maria; Rivera, Jocelyn; Sniderman, Elizabeth; Wrigley, Jordan; Zafar, Huma; Agulnik, Asya.
Afiliación
  • Gabela A; University of Tennessee Health Science Center, Memphis, TN 38103, United States. Electronic address: alejandra.gabela@stjude.org.
  • Wösten-van Asperen RM; Department of Pediatric Intensive Care, University Medical Center Utrecht/Wilhelmina Children's Hospital, Utrecht, Netherlands. Electronic address: r.m.vanasperen@umcutrecht.nl.
  • Arias AV; Departments of Pediatrics, Division of Critical Care and Pulmonary Medicine, at St. Jude Children's Research Hospital, Memphis, TN 38105, United States. Electronic address: anita.arias@stjude.org.
  • Acuña C; Departments of Pediatric Intensive Care Unit and Neonatal intensive Care Unit, Hospital Dr. Luis Calvo Mackenna, Santiago 7500967, Chile. Electronic address: cacuna@calvomackenna.cl.
  • Zebin ZA; Department of Pediatrics, King Hussein Cancer Center, Amman 11181, Jordan. Electronic address: zabenaz@gmail.com.
  • Lopez-Baron E; Division of Critical Care, Department of Pediatrics, Hospital Pablo Tobón Uribe, Universidad de Antioquia. Medellín 69240, Colombia. Electronic address: lopezb.eliana@gmail.com.
  • Bhattacharyya P; Department of Paediatric Onco-Critical Care Unit, Hospital Tata Medical Center, Kolkata 700 160, India. Electronic address: pbhattacharyya65@gmail.com.
  • Duncanson L; Department of Pediatrics, Lebonheur Children's Hospital. Affiliated to University of Tennessee Health Science Center, Memphis, TN 38103, United States. Electronic address: lduncans@uthsc.edu.
  • Ferreira D; Department of Bone Marrow Transplant Intensive Care Unit and Department Onco-Critical Care Unit, Barretos Children's Cancer Hospital, Barretos 14784-005, Brazil. Electronic address: dfferreirabtos@gmail.com.
  • Gunasekera S; Department of Paediatrics, National Cancer Institute, Maharagama 10280, Sri Lanka. Electronic address: guntimail@gmail.com.
  • Hayes S; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN 38105, United States. Electronic address: samantha.hayes@stjude.org.
  • McArthur J; Department of Pediatrics, St. Jude Children's Research Hospital, Memphis, TN 38105, United States. Electronic address: jennifer.mcarthur@stjude.org.
  • Nagarajan VD; Division of Critical Care, Department of Pediatrics, Doernbecher Children's Hospital, Oregon Health & Science University, Portland, OR 97239, United States. Electronic address: v.divyanagraj@gmail.com.
  • Puerto Torres M; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN 38105, United States. Electronic address: maria.puertotorres@stjude.org.
  • Rivera J; Division of Emergency Department, Department of Pediatric, Hospital Infantil Teleton de Oncología Emergency, Queretaro 76140, Mexico. Electronic address: jocelyn.rivera@stjude.org.
  • Sniderman E; Department of Oncology Northern Alberta Children's Cancer Program, Stollery Children's Hospital, Alberta T6G2B7, Canada. Electronic address: liz.sniderman@gmail.com.
  • Wrigley J; Data and policy analyst for Health & Wellness at the Future of Privacy Forum and a systematic review specialist consultant at St. Jude Children's Research Hospital. Affiliated to Duke Medical Center Library, Durham, NC 27710, United States. Electronic address: jeliwrig@gmail.com.
  • Zafar H; Department of Pediatric Hematology/ Oncology and Bone Marrow Transplant Unit, University of Child Health Sciences, The Children's Hospital, Lahore 54600, Pakistan. Electronic address: humazafar33@yahoo.com.
  • Agulnik A; Division of Critical Care, Department of Pediatrics and Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN 38105, United States. Electronic address: asya.agulnik@stjude.org.
Crit Rev Oncol Hematol ; 203: 104467, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39127134
ABSTRACT

BACKGROUND:

Pediatric oncology patients have increased risk for critical illness; outcomes are well described in high-income countries (HICs); however, data is limited for low- and middle-income countries (LMICs).

METHODS:

We systematically searched PubMed, EMBASE, Web of Science, CINAHL and Global Health databases for articles in 6 languages describing mortality in children with cancer admitted to intensive care units (ICUs) in LMICs. Two investigators independently assessed eligibility, data quality, and extracted data. We pooled ICU mortality estimates using random effect models.

RESULTS:

Of 3641 studies identified, 22 studies were included, covering 4803 ICU admissions. Overall pooled mortality was 30.3 % [95 % Confidence-interval (CI) 21.7-40.6 %]. Mechanical ventilation [odds ratio (OR) 12.2, 95 %CI6.2-24.0, p-value<0.001] and vasoactive infusions [OR 6.3 95 %CI3.3-11.9, p-value<0.001] were associated with ICU mortality.

CONCLUSIONS:

ICU mortality among pediatric oncology patients in LMICs is similar to that in HICs, however, this review likely underestimates true mortality due to underrepresentation of studies from low-income countries.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Crítica / Países en Desarrollo / Neoplasias Límite: Child / Humans Idioma: En Revista: Crit Rev Oncol Hematol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad Crítica / Países en Desarrollo / Neoplasias Límite: Child / Humans Idioma: En Revista: Crit Rev Oncol Hematol Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos