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Effect of Alcohol on Clock Synchrony and Tissue Circadian Homeostasis in Mice.
Santovito, Luca S; Shaikh, Maliha; Sharma, Deepak; Forsyth, Christopher B; Voigt, Robin M; Keshavarzian, Ali; Bishehsari, Faraz.
Afiliación
  • Santovito LS; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL, 60612, USA.
  • Shaikh M; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL, 60612, USA.
  • Sharma D; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL, 60612, USA.
  • Forsyth CB; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL, 60612, USA.
  • Voigt RM; Departments of Medicine, Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL, 60612, USA.
  • Keshavarzian A; Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL, 60612, USA.
  • Bishehsari F; Departments of Medicine, Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL, 60612, USA.
Mol Nutr Food Res ; 68(16): e2400234, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39126133
ABSTRACT
Alcohol use disorder accounts for a growing worldwide health system concern. Alcohol causes damages to various organs, including intestine and liver, primarily involved in its absorption and metabolism. However, alcohol-related organ damage risk varies significantly among individuals, even when they report consuming comparable dosages of alcohol. Factor(s) that may modulate the risk of organ injuries from alcohol consumption could be responsible for inter-individual variations in susceptibility to alcohol-related organ damages. Accumulating evidence suggests disruptions in circadian rhythm can exacerbate alcohol-related organ damages. Here we investigated the interplay between alcohol, circadian rhythm, and key tissue cellular processes at baseline, after a regular and a shift in the light/dark cycle (LCD) in mice. Central/peripheral clock expression of core clock genes (CoClGs) was analyzed. We also studied circadian homeostasis of tissue cellular processes that are involved in damages from alcohol. These experiments reveal that alcohol affects the expression of CoClGs causing a central-peripheral dyssynchrony, amplified by shift in LCD. The observed circadian clock dyssynchrony was linked to circadian disorganization of key processes involved in the alcohol-related damages, particularly when alcohol was combined with LCD. These results offer insights into the mechanisms by which alcohol interacts with circadian rhythm disruption to promote organ injury.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ritmo Circadiano / Etanol / Homeostasis / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ritmo Circadiano / Etanol / Homeostasis / Ratones Endogámicos C57BL Límite: Animals Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania