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Identification of Oxidative Stress-Related Biomarkers for Pain-Depression Comorbidity Based on Bioinformatics.
Zhang, Tianyun; Geng, Menglu; Li, Xiaoke; Gu, Yulin; Zhao, Wenjing; Ning, Qi; Zhao, Zijie; Wang, Lei; Zhang, Huaxing; Zhang, Fan.
Afiliación
  • Zhang T; Postdoctoral Research Station in Biology, Hebei Medical University, Shijiazhuang 050017, China.
  • Geng M; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Center for Brain Science and Disease, Hebei Medical University, Shijiazhuang 050017, China.
  • Li X; Laboratory of Neurobiology, Hebei Medical University, Shijiazhuang 050017, China.
  • Gu Y; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Center for Brain Science and Disease, Hebei Medical University, Shijiazhuang 050017, China.
  • Zhao W; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Center for Brain Science and Disease, Hebei Medical University, Shijiazhuang 050017, China.
  • Ning Q; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Center for Brain Science and Disease, Hebei Medical University, Shijiazhuang 050017, China.
  • Zhao Z; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Center for Brain Science and Disease, Hebei Medical University, Shijiazhuang 050017, China.
  • Wang L; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Center for Brain Science and Disease, Hebei Medical University, Shijiazhuang 050017, China.
  • Zhang H; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Center for Brain Science and Disease, Hebei Medical University, Shijiazhuang 050017, China.
  • Zhang F; Postdoctoral Research Station in Biology, Hebei Medical University, Shijiazhuang 050017, China.
Int J Mol Sci ; 25(15)2024 Jul 30.
Article en En | MEDLINE | ID: mdl-39125922
ABSTRACT
Oxidative stress has been identified as a major factor in the development and progression of pain and psychiatric disorders, but the underlying biomarkers and molecular signaling pathways remain unclear. This study aims to identify oxidative stress-related biomarkers and signaling pathways in pain-depression comorbidity. Integrated bioinformatics analyses were applied to identify key genes by comparing pain-depression comorbidity-related genes and oxidative stress-related genes. A total of 580 differentially expressed genes and 35 differentially expressed oxidative stress-related genes (DEOSGs) were identified. By using a weighted gene co-expression network analysis and a protein-protein interaction network, 43 key genes and 5 hub genes were screened out, respectively. DEOSGs were enriched in biological processes and signaling pathways related to oxidative stress and inflammation. The five hub genes, RNF24, MGAM, FOS, and TKT, were deemed potential diagnostic and prognostic markers for patients with pain-depression comorbidity. These genes may serve as valuable targets for further research and may aid in the development of early diagnosis, prevention strategies, and pharmacotherapy tools for this particular patient population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Biomarcadores / Comorbilidad / Estrés Oxidativo / Biología Computacional / Depresión / Redes Reguladoras de Genes / Mapas de Interacción de Proteínas Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Biomarcadores / Comorbilidad / Estrés Oxidativo / Biología Computacional / Depresión / Redes Reguladoras de Genes / Mapas de Interacción de Proteínas Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza