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Novel Thermosensitive and Mucoadhesive Nasal Hydrogel Containing 5-MeO-DMT Optimized Using Box-Behnken Experimental Design.
Miranda, Pablo; Castro, Analía; Díaz, Paola; Minini, Lucía; Ferraro, Florencia; Paulsen, Erika; Faccio, Ricardo; Pardo, Helena.
Afiliación
  • Miranda P; Unidad de Nanotecnología, Instituto Polo Tecnológico de Pando, Facultad de Química, Universidad de la República, Montevideo 91000, Uruguay.
  • Castro A; Unidad de Nanotecnología, Instituto Polo Tecnológico de Pando, Facultad de Química, Universidad de la República, Montevideo 91000, Uruguay.
  • Díaz P; Biomind Labs, Brookfield Place, 181 Bay Street, Suite 1800, Toronto, ON M5J 2T9, Canada.
  • Minini L; Biomind Labs, Brookfield Place, 181 Bay Street, Suite 1800, Toronto, ON M5J 2T9, Canada.
  • Ferraro F; Biomind Labs, Brookfield Place, 181 Bay Street, Suite 1800, Toronto, ON M5J 2T9, Canada.
  • Paulsen E; Instituto de Ingeniería Química, Facultad de Ingeniería, Universidad de la República, Montevideo 11800, Uruguay.
  • Faccio R; Área Física, DETEMA, Facultad de Química, Universidad de la República, Montevideo 11300, Uruguay.
  • Pardo H; Unidad de Nanotecnología, Instituto Polo Tecnológico de Pando, Facultad de Química, Universidad de la República, Montevideo 91000, Uruguay.
Polymers (Basel) ; 16(15)2024 Jul 29.
Article en En | MEDLINE | ID: mdl-39125174
ABSTRACT
We present the development and characterization of a nasal drug delivery system comprised of a thermosensitive mucoadhesive hydrogel based on a mixture of the polymers Poloxamer 407, Poloxamer 188 and Hydroxypropyl-methylcellulose, and the psychedelic drug 5-methoxy-N,-N-dimethyltryptamine. The development relied on a 3 × 3 Box-Behnken experimental design, focusing on optimizing gelification temperature, viscosity and mucoadhesion. The primary objective of this work was to tailor the formulation for efficient nasal drug delivery. This would increase contact time between the hydrogel and the mucosa while preserving normal ciliary functioning. Following optimization, the final formulation underwent characterization through an examination of the in vitro drug release profile via dialysis under sink conditions. Additionally, homogeneity of its composition was assessed using Raman Confocal Spectroscopy. The results demonstrate complete mixing of drug and polymers within the hydrogel matrix. Furthermore, the formulation exhibits sustained release profile, with 73.76% of the drug being delivered after 5 h in vitro. This will enable future studies to assess the possibility of using this formulation to treat certain mental disorders. We have successfully developed a promising thermosensitive and mucoadhesive hydrogel with a gelling temperature of around 32 °C, a viscosity close to 100 mPas and a mucoadhesion of nearly 4.20 N·m.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Polymers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Uruguay Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Polymers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Uruguay Pais de publicación: Suiza