Your browser doesn't support javascript.
loading
Efficacy and Safety of Magnesium Sulfate as an Adjunct to Ropivacaine Wound Infiltration in Thyroid Surgery: A Prospective, Double-Blind, Randomized Controlled Trial.
Laskou, Stiliani; Tsaousi, Georgia; Pourzitaki, Chryssa; Papazisis, Georgios; Kesisoglou, Isaak; Sapalidis, Konstantinos.
Afiliación
  • Laskou S; 3rd Surgical Department, School of Medicine, Aristotle University of Thessaloniki, 1st St. Kiriakidi Str, 54636 Thessaloniki, Greece.
  • Tsaousi G; Clinic of Anesthesiology and Intensive Care, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
  • Pourzitaki C; Department of Clinical Pharmacology, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece.
  • Papazisis G; Department of Clinical Pharmacology, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece.
  • Kesisoglou I; 3rd Surgical Department, School of Medicine, Aristotle University of Thessaloniki, 1st St. Kiriakidi Str, 54636 Thessaloniki, Greece.
  • Sapalidis K; 3rd Surgical Department, School of Medicine, Aristotle University of Thessaloniki, 1st St. Kiriakidi Str, 54636 Thessaloniki, Greece.
J Clin Med ; 13(15)2024 Aug 01.
Article en En | MEDLINE | ID: mdl-39124765
ABSTRACT
Background/

Objective:

Wound infiltration with local anesthetics emerges as a promising modality for postoperative pain alleviation. However, such strategies in neck surgery have not been a well-established practice. To assess wound infiltration with ropivacaine plus magnesium sulfate for pain relief following thyroid surgery.

Methods:

This prospective, double-blind, randomized study enrolled 68 patients who underwent thyroid surgery. Concerning the solution used for surgical wound infiltration, the study participants were randomly allocated into three groups (1) 100 mg of ropivacaine (Group R); (2) 100 mg of ropivacaine plus magnesium sulfate 10 mg/kg (Group RMg); and (3) normal saline which served as a placebo (Group P). Pain perception both at rest and at movement, was measured using the Visual Analogue Scale (VAS) at 30 min, as well as at 1, 2, 4, 6, 12, and 24 h postoperatively. The total consumption of analgesics in morphine equivalents was also recorded. Moreover, adverse effects and patient satisfaction were recorded. Cortisol, TNF-α, and IL-6 levels were measured 30 min before infiltration and 6 h and 24 h postoperatively.

Results:

Demographics and clinical characteristics were similar between the groups. The VAS scores at rest and during movement were significantly lower in the RMg group compared to the saline or ropivacaine groups. Total analgesic consumption was also significantly lower in the RMg group. No operation-, wound-, or infiltration-related adverse effects were recorded in the study groups. Better overall satisfaction was obtained for the RMg group.

Conclusions:

Ropivacaine plus magnesium sulfate wound infiltration provided better pain control and the analgesic effect was more significant, contributing to effective postoperative analgesia in patients undergoing thyroid surgery.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Suiza