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A Mature Tertiary Lymphoid Structure with a Ki-67-Positive Proliferating Germinal Center Is Associated with a Good Prognosis and High Intratumoral Immune Cell Infiltration in Advanced Colorectal Cancer.
Mori, Natsumi; Dorjkhorloo, Gendensuren; Shiraishi, Takuya; Erkhem-Ochir, Bilguun; Okami, Haruka; Yamaguchi, Arisa; Shioi, Ikuma; Komine, Chika; Endo, Mizuki; Seki, Takaomi; Hosoi, Nobuhiro; Nakazawa, Nobuhiro; Shibasaki, Yuta; Okada, Takuhisa; Osone, Katsuya; Sano, Akihiko; Sakai, Makoto; Sohda, Makoto; Yokobori, Takehiko; Shirabe, Ken; Saeki, Hiroshi.
Afiliación
  • Mori N; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Dorjkhorloo G; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Shiraishi T; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Erkhem-Ochir B; Division of Gene Therapy Science, Gunma University Initiative for Advanced Research (GIAR), Maebashi 371-8511, Japan.
  • Okami H; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Yamaguchi A; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Shioi I; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Komine C; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Endo M; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Seki T; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Hosoi N; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Nakazawa N; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Shibasaki Y; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Okada T; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Osone K; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Sano A; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Sakai M; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Sohda M; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Yokobori T; Division of Gene Therapy Science, Gunma University Initiative for Advanced Research (GIAR), Maebashi 371-8511, Japan.
  • Shirabe K; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
  • Saeki H; Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
Cancers (Basel) ; 16(15)2024 Jul 28.
Article en En | MEDLINE | ID: mdl-39123412
ABSTRACT
Tertiary lymphoid structures (TLSs) are complex lymphocyte clusters that arise in non-lymphoid tissues due to inflammation or cancer. A mature TLS with proliferating germinal centers is associated with a favorable prognosis in various cancers. However, the effect of TLS maturity on advanced colorectal cancer (CRC) remains unexplored. We analyzed the significance of TLS maturity and tumor Ki-67 expression in surgically resected tumors from 78 patients with pathological T4 CRC. Mature TLS was defined as the organized infiltration of T and B cells with Ki-67-positive proliferating germinal centers. We analyzed the relationship between TLS maturity and intratumoral immune cell infiltration. Mature TLS with germinal center Ki-67 expression was associated with microsatellite instability and improved survival; however, high tumor Ki-67 expression was associated with poor survival in the same cohort. Multivariate analysis identified the absence of mature TLS as an independent predictor of poor post-recurrence overall survival. Intratumoral infiltration of T lymphocytes and macrophages was significantly elevated in tumors with mature TLS compared to those lacking it. High Ki-67 levels and absent mature TLS were identified as poor prognostic factors in advanced CRC. Mature TLS could serve as a promising marker for patients at high-risk of CRC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza