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Adjuvant Therapy with Immune Checkpoint Inhibitors after Carbon Ion Radiotherapy for Mucosal Melanoma of the Head and Neck: A Case-Control Study.
Mizoguchi, Nobutaka; Kano, Kio; Okuda, Tatsuya; Koge, Hiroaki; Shima, Satoshi; Tsuchida, Keisuke; Takakusagi, Yosuke; Kawashiro, Shohei; Yoshida, Manatsu; Kitani, Yuka; Hashimoto, Kaori; Furukawa, Madoka; Shirai, Katsuyuki; Kamada, Tadashi; Yoshida, Daisaku; Katoh, Hiroyuki.
Afiliación
  • Mizoguchi N; Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama 241-8515, Japan.
  • Kano K; Department of Radiology, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Japan.
  • Okuda T; Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama 241-8515, Japan.
  • Koge H; Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama 241-8515, Japan.
  • Shima S; Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama 241-8515, Japan.
  • Tsuchida K; Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama 241-8515, Japan.
  • Takakusagi Y; Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama 241-8515, Japan.
  • Kawashiro S; Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama 241-8515, Japan.
  • Yoshida M; Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama 241-8515, Japan.
  • Kitani Y; Department of Head and Neck Surgery, Kanagawa Cancer Center, Yokohama 241-8515, Japan.
  • Hashimoto K; Department of Head and Neck Surgery, Kanagawa Cancer Center, Yokohama 241-8515, Japan.
  • Furukawa M; Department of Head and Neck Surgery, Kanagawa Cancer Center, Yokohama 241-8515, Japan.
  • Shirai K; Department of Head and Neck Surgery, Kanagawa Cancer Center, Yokohama 241-8515, Japan.
  • Kamada T; Department of Radiology, Jichi Medical University Saitama Medical Center, Saitama 330-8503, Japan.
  • Yoshida D; Department of Radiation Oncology, Jichi Medical University Hospital, Tochigi 329-0498, Japan.
  • Katoh H; Department of Radiation Oncology, Kanagawa Cancer Center, Yokohama 241-8515, Japan.
Cancers (Basel) ; 16(15)2024 Jul 23.
Article en En | MEDLINE | ID: mdl-39123353
ABSTRACT
The development of new treatment strategies to improve the prognosis of mucosal malignant melanoma of the head and neck (MMHN) after carbon ion radiotherapy (CIRT) is essential because of the risk of distant metastases. Therefore, our objective was to evaluate the outcomes of immune checkpoint inhibitor (ICI) treatment to justify its inclusion in the regimen after CIRT. Thirty-four patients who received CIRT as an initial treatment were included in the analysis and stratified into three groups those who did not receive ICIs (Group A), those who received ICIs after recurrence or metastasis (Group B), and those who received ICIs as adjuvant therapy after CIRT (Group C). In total, 62% of the patients (n = 21) received ICIs. The 2-year local control and overall survival (OS) rates for all patients were 90.0% and 66.8%, respectively. The 2-year OS rates for patients in Groups A, B, and C were 50.8%, 66.7%, and 100%, respectively. No significant differences were observed between Groups A and B (p = 0.192) and Groups B and C (p = 0.112). However, a significant difference was confirmed between Groups A and C (p = 0.017). Adjuvant therapy following CIRT for MMHN may be a promising treatment modality that can extend patient survival.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza