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Non-dialyzable uremic toxins and renal tubular cell damage in CKD patients: a systems biology approach.
Asadi, Roya; Shadpour, Pejman; Nakhaei, Akram.
Afiliación
  • Asadi R; Industrial Engineering Department, Faculty of Technical and Engineering, University of Science and Culture (USC), Tehran, Iran.
  • Shadpour P; Hospital Management Research Center (HMRC), Hasheminejad Kidney Center (HKC), Iran University of Medical Sciences (IUMS), Tehran, Iran. pshadpour@gmail.com.
  • Nakhaei A; Computer Engineering Department, Mazandaran University of Science and Technology (MUST), Babol, Iran. a.nakhaee.66@gmail.com.
Eur J Med Res ; 29(1): 412, 2024 Aug 09.
Article en En | MEDLINE | ID: mdl-39123228
ABSTRACT

BACKGROUND:

Chronic kidney disease presents global health challenges, with hemodialysis as a common treatment. However, non-dialyzable uremic toxins demand further investigation for new therapeutic approaches. Renal tubular cells require scrutiny due to their vulnerability to uremic toxins.

METHODS:

In this study, a systems biology approach utilized transcriptomics data from healthy renal tubular cells exposed to healthy and post-dialysis uremic plasma.

RESULTS:

Differential gene expression analysis identified 983 up-regulated genes, including 70 essential proteins in the protein-protein interaction network. Modularity-based clustering revealed six clusters of essential proteins associated with 11 pathological pathways activated in response to non-dialyzable uremic toxins.

CONCLUSIONS:

Notably, WNT1/11, AGT, FGF4/17/22, LMX1B, GATA4, and CXCL12 emerged as promising targets for further exploration in renal tubular pathology related to non-dialyzable uremic toxins. Understanding the molecular players and pathways linked to renal tubular dysfunction opens avenues for novel therapeutic interventions and improved clinical management of chronic kidney disease and its complications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biología de Sistemas / Insuficiencia Renal Crónica / Tóxinas Urémicas / Túbulos Renales Límite: Humans Idioma: En Revista: Eur J Med Res Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biología de Sistemas / Insuficiencia Renal Crónica / Tóxinas Urémicas / Túbulos Renales Límite: Humans Idioma: En Revista: Eur J Med Res Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido