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Targeted discovery of clerodane diterpenoids from Tinospora sinensis as immunomodulatory agents.
Ao, Rui; Li, Meng-Yao; Yang, Fei-Fei; Bao, Jie; Zhang, Jun-Sheng; Zhang, Hua.
Afiliación
  • Ao R; School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China.
  • Li MY; School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China.
  • Yang FF; School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China.
  • Bao J; School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China.
  • Zhang JS; School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China. Electronic address: bio_zhangjs@ujn.edu.cn.
  • Zhang H; School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China. Electronic address: bio_zhangh@ujn.edu.cn.
Fitoterapia ; 178: 106174, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39122119
ABSTRACT
Under the guidance of MS/MS-based molecular networking, five new clerodane diterpenoid glucosides, tinosinesides R-V (1-5), along with 15 known diterpenoids (6-20), were isolated from the stems of Tinospora sinensis. Compound 1 represents the first example of diterpenoid bearing a thio sugar and compound 5 is the first 18,19-dinor-clerodane with cis-fused A/B ring. The structures of the new compounds were elucidated by spectroscopic means, and their absolute configurations were established on the basis of time-dependent density functional theory (TD-DFT) based electronic circular dichroism (ECD) calculation and chemical methods. Selected compounds were evaluated for their immunomodulatory effect and several compounds could enhance the proliferation of B lymphocytes. Preliminary mechanistic studies disclosed that 3 could promote B cell generation and inhibit B cell differentiation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos B / Tinospora / Diterpenos de Tipo Clerodano / Fitoquímicos Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos B / Tinospora / Diterpenos de Tipo Clerodano / Fitoquímicos Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos