Drug tolerance and persistence in bacteria, fungi and cancer cells: Role of non-genetic heterogeneity.
Transl Oncol
; 49: 102069, 2024 Nov.
Article
en En
| MEDLINE
| ID: mdl-39121829
ABSTRACT
A common feature of bacterial, fungal and cancer cell populations upon treatment is the presence of tolerant and persistent cells able to survive, and sometimes grow, even in the presence of usually inhibitory or lethal drug concentrations, driven by non-genetic differences among individual cells in a population. Here we review and compare data obtained on drug survival in bacteria, fungi and cancer cells to unravel common characteristics and cellular pathways, and to point their singularities. This comparative work also allows to cross-fertilize ideas across fields. We particularly focus on the role of gene expression variability in the emergence of cell-cell non-genetic heterogeneity because it represents a possible common basic molecular process at the origin of most persistence phenomena and could be monitored and tuned to help improve therapeutic interventions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Transl Oncol
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos