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Moderate physical activity during neoadjuvant chemotherapy in breast cancer patients: effect on cancer-related inflammation and pathological complete response-the Neo-Runner study.
Garrone, O; Paccagnella, M; Abbona, A; Ruatta, F; Vanella, P; Denaro, N; Tomasello, G; Croce, N; Barbin, F; Rossino, M G; La Porta, C A M; Sapino, A; Torri, V; Albini, A; Merlano, M C.
Afiliación
  • Garrone O; Department of Medical Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan. Electronic address: ornella.garrone@policlinico.mi.it.
  • Paccagnella M; Translational Oncology ARCO Foundation, Cuneo. Electronic address: https://twitter.com/matteo_babeuf.
  • Abbona A; Translational Oncology ARCO Foundation, Cuneo. Electronic address: https://twitter.com/AbbonaAndr36863.
  • Ruatta F; Department of Medical Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan. Electronic address: https://twitter.com/fiorella_ruatta.
  • Vanella P; Department of Medical Oncology, S. Croce e Carle Teaching Hospital, Cuneo.
  • Denaro N; Department of Medical Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan.
  • Tomasello G; Medical Oncology, ASST Ospedale Maggiore Crema, Crema. Electronic address: https://twitter.com/glucatom.
  • Croce N; Department of Medical Oncology, S. Croce e Carle Teaching Hospital, Cuneo.
  • Barbin F; Department of Medical Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan.
  • Rossino MG; Department of Medical Oncology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan.
  • La Porta CAM; Center for Complexity and Biosystems, University of Milan, Milan; Department of Environmental Science and Policy, University of Milan, Milan. Electronic address: https://twitter.com/CAMLaPorta.
  • Sapino A; Scientific Direction, Candiolo Cancer Institute, FPO-IRCCS Candiolo, Turin; Department of Medical Science, University of Turin, Turin. Electronic address: https://twitter.com/sapino58.
  • Torri V; Mario Negri Institute for Pharmacological Research, Milan. Electronic address: https://twitter.com/ValterTorri.
  • Albini A; European Institute of Oncology, Milan, Italy. Electronic address: https://twitter.com/adrianaalbini1.
  • Merlano MC; Scientific Direction, Candiolo Cancer Institute, FPO-IRCCS Candiolo, Turin.
ESMO Open ; 9(8): 103665, 2024 Aug.
Article en En | MEDLINE | ID: mdl-39121813
ABSTRACT

BACKGROUND:

Physical activity (PA) reduces the risk of developing breast cancer (BC) and mortality rate in BC patients starting PA after diagnosis. Immunomodulation is considered responsible for these effects. However, limited data exist on the immunomodulation induced by moderate PA (mPA) during neoadjuvant chemotherapy (NACT). We have investigated the longitudinal change of cytokines during NACT alone or combined with mPA. MATERIALS AND

METHODS:

Twenty-three cytokines were analyzed in BC patients at consecutive timepoints at baseline (T0), before starting mPA (T1), before surgery (T2), and after surgery (T3). mPA consisted of 3-weekly brisk-walking sessions for 9-10 consecutive weeks.

RESULTS:

Ninety-two patients were assessed 21 patients refused mPA (untrained) and 71 agreed (trained). At T1, NACT induced significant up-regulation of interleukin (IL)-5, IL-6, IL-15, chemokine ligand (CCL)-2, interferon-γ, and C-X-C motif ligand (CXCL)-10 and reduction of expression of IL-13 and CCL-22. At T2, NACT and mPA induced up-regulation of IL-21, CCL-2, and tumor necrosis factor-α and reduction of expression of IL-8, IL-15, vascular endothelial growth factor, and soluble interleukin 6 receptor. Only CXCL-10 increased in untrained patients. A cytokine score (CS) was created to analyze, all together, the changes between T1 and T2. At T2 the CS decreased in trained and increased in untrained patients. We clustered the patients using cytokines and predictive factors and identified two clusters. The cluster A, encompassing 90% of trained patients, showed more pathological complete response (pCR) compared to the cluster B 78% versus 22%, respectively.

CONCLUSIONS:

mPA interacts with NACT inducing CS reduction in trained patients not observed in untrained patients, suggesting a reduction of inflammation, notwithstanding chemotherapy. This effect may contribute to the higher rate of pCR observed in the cluster A, including most trained patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Ejercicio Físico / Citocinas / Terapia Neoadyuvante / Inflamación Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: ESMO Open Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Ejercicio Físico / Citocinas / Terapia Neoadyuvante / Inflamación Límite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: ESMO Open Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido