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Administering Intravitreal Bevacizumab for Retinopathy of Prematurity: 8-Year Cognitive Outcomes in a Prospective Cohort.
Wu, Pei-Liang; Shih, Chia-Pang; Huang, Yu-Shu; Chen, Hung-Chi; Hsueh, Yi-Jen; Lee, Chia-Wen; Chiang, Ming-Chou; Lien, Reyin; Lee, Chien-Chung; Chu, Shih-Ming; Chou, Hung-Da; Liu, Laura; Chen, Kuan-Jen; Huang, Yih-Shiou; Lai, Chi-Chun; Wu, Wei-Chi.
Afiliación
  • Wu PL; Department of Medicine, National Taiwan University, Taipei, Taiwan.
  • Shih CP; Department of Nursing, Yuanpei University of Medical Technology, Hsinchu, Taiwan.
  • Huang YS; Department of Child Psychiatry and Sleep Center, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.
  • Chen HC; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Hsueh YJ; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Lee CW; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Taiwan.
  • Chiang MC; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Lien R; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Taiwan.
  • Lee CC; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Chu SM; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Taiwan.
  • Chou HD; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Liu L; Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taiwan.
  • Chen KJ; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Huang YS; Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taiwan.
  • Lai CC; College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Wu WC; Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taiwan.
Retina ; 2024 Aug 12.
Article en En | MEDLINE | ID: mdl-39121508
ABSTRACT

PURPOSE:

Determine whether intravitreal injection of bevacizumab (IVB) exerts long-term effects on neurodevelopmental outcomes in children with retinopathy of prematurity (ROP) when reaching the age of 8 years.

METHODS:

We enrolled 277 children. Patients were stratified into the groups full-term, preterm without ROP, ROP without treatment, or ROP with treatment, based on gestational age (GA) and ROP status. Children under GA of 37 weeks were considered premature. Patients' cognitive outcomes were evaluated using Full-Scale Intelligence Quotient (FIQ) (full score and percentile) generated by the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) every 1 to 2 years.

RESULTS:

At the mean age of 7.8 years, ROP without and with treatment groups demonstrated lower FIQ scores and percentiles, compared with full-term and premature groups (both p<0.05). FIQ scores and percentiles didn't significantly differ between patients who received different treatments for ROP (full score p=0.19; percentile p=0.37). After adjusting for GA, LogMAR best corrected visual acuity (BCVA) was negatively associated with FIQ scores (p=0.0008) and percentiles (p=0.0002).

CONCLUSIONS:

At the mean age of 8 years, patients with ROP undergoing IVB didn't exhibit worse cognitive outcomes than those who underwent laser photocoagulation or both treatments. GA and BCVA correlated with cognitive development in children.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Retina Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Retina Año: 2024 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Estados Unidos