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(+)-Catechins Play a Protective Role in Diabetic Kidney Disease by Alleviating EMT through Multiple Pathways.
Ni, Ying; Zhu, Dina; Chen, Chao; Wang, Fan; Miu, Yanyan; Zhang, Wensheng.
Afiliación
  • Ni Y; Engineering Research Center of Natural Medicine, Ministry of Education, Beijing Normal University at Zhuhai, Zhuhai, 519087, China.
  • Zhu D; Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical, Science, Beijing Normal University, Beijing, 100875, China.
  • Chen C; Zhuhai Branch of State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University at Zhuhai, Zhuhai, 519087, China.
  • Wang F; Engineering Research Center of Natural Medicine, Ministry of Education, Beijing Normal University at Zhuhai, Zhuhai, 519087, China.
  • Miu Y; Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Faculty of Geographical, Science, Beijing Normal University, Beijing, 100875, China.
  • Zhang W; Zhuhai Branch of State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University at Zhuhai, Zhuhai, 519087, China.
Mol Nutr Food Res ; : e2400387, 2024 Aug 09.
Article en En | MEDLINE | ID: mdl-39121356
ABSTRACT
SCOPE Diabetic nephropathy (DN), a complication of diabetes mellitus, is becoming a significant global health concern, with no complete cure currently available. Tea is regarded as an essential component of a balanced diet and contains (+)-Catechin (CE), which exert a range of pharmacological effects. Consequently, CE may be a potential treatment for DN. The objective of this study is to examine the protective effects and underlying mechanisms of CE on DN, with a particular focus on the epithelial-mesenchymal transition (EMT) process, which plays a pivotal role in regulating DN. METHODS AND

RESULTS:

In this study db/db mice are treated with catechins. The results demonstrate that CE reduces obesity and hyperglycemia, improves renal dysfunction and morphological changes in diabetic mice, and inhibits the development of DN through the RAGE/NF-κB signaling pathway. Among them differentially expressed messenger RNA (mRNA) results, those related to EMT, including Cav1, grem2, macrod2, and kap, are identified. To further validate the results, the same experiments are performed on HK-2 cells.

CONCLUSIONS:

The research results offer novel perspectives by emphasizing the anti-inflammatory properties of CE and their potential role in mitigating DN through the regulation of EMT-related genes such as RAGE, Cav1, grem2, macrod2, and kap.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mol Nutr Food Res Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania