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Impact of hydrophobic modification on biocompatibility of Alaska pollock gelatin microparticles.
Yee, Ying Chuin; Mori, Takeshi; Ito, Shima; Taguchi, Tetsushi; Katayama, Yoshiki.
Afiliación
  • Yee YC; Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.
  • Mori T; Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan. mori.takeshi.880@m.kyushu-u.ac.jp.
  • Ito S; Center for Future Chemistry, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan. mori.takeshi.880@m.kyushu-u.ac.jp.
  • Taguchi T; Degree Programs in Pure and Applied Sciences, Graduate School of Science and Technology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.
  • Katayama Y; Biomaterials Field, Research Center for Macromolecules and Biomaterials, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
Anal Sci ; 40(11): 2053-2061, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39120821
ABSTRACT
This study investigates the impact of hydrophobic modification on the immunogenicity, cytotoxicity, and inflammatory response of Alaska pollock gelatin (ApGltn) microparticles (MPs). Gelatin, known for its inherent biocompatibility, was modified with decyl group (C10) to explore potential alterations in its interaction with the immune system. Immunogenicity was evaluated through the measurement of material-specific IgM and IgG responses, indicating no significant increase post-modification. Cytotoxicity against Caco-2 cell lines and NF-κB-mediated LPS-induced inflammation were also assessed, revealing no exacerbation by the modified MPs. Furthermore, C10 modification with different types of linkage such as secondary amine and amide structure did not influence immune reactivity. These findings suggest that C10 modification maintains the non-immunogenicity and biocompatibility of gelatin MPs, supporting their potential use in biomedical applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interacciones Hidrofóbicas e Hidrofílicas / Gelatina Límite: Animals / Humans Idioma: En Revista: Anal Sci Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interacciones Hidrofóbicas e Hidrofílicas / Gelatina Límite: Animals / Humans Idioma: En Revista: Anal Sci Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza