Vitamin D therapy in chronic kidney disease: a critical appraisal of clinical trial evidence.

Yeung, Wing-Chi G; Toussaint, Nigel D; Badve, Sunil V

Yeung, Wing-Chi G; Toussaint, Nigel D; Badve, Sunil V.

Afiliación

Yeung WG; Department of Nephrology, Wollongong Hospital, Wollongong, New South Wales, Australia.
Toussaint ND; Renal and Metabolic Division, The George Institute for Global Health, Sydney, New South Wales, Australia.
Badve SV; Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.

Clin Kidney J ; 17(8): sfae227, 2024 Aug.

Article en En | MEDLINE | ID: mdl-39119524

ABSTRACT

ABSTRACT

In people with chronic kidney disease (CKD), the physiology of vitamin D is altered and leads to abnormalities in bone and mineral metabolism which contribute to CKD mineral and bone disorder (CKD-MBD). Observational studies show an association between vitamin D deficiency and increased risk of mortality, cardiovascular disease and fracture in CKD. Although vitamin D therapy is widely prescribed in people with CKD, clinical trials to date have failed to demonstrate a clear benefit of either nutritional vitamin D supplementation or active vitamin D therapy in improving clinical outcomes in CKD. This review provides an updated critical analysis of recent trial evidence on vitamin D therapy in people with CKD.

Palabras clave

CKD-MBD; bone health; cardiovascular disease; chronic kidney disease; vitamin D

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Kidney J Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido

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