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Fusible and Radiopaque Microspheres for Embolization.
Li, Jing; Xu, Jingyi; Wang, Yunpeng; Chen, Yue; Ding, Yuanyuan; Gao, Wenxia; Tan, Yexiong; Ge, Naijian; Chen, Yibin; Ge, Shennian; Yang, Qi; He, Bin; Ye, Xueting.
Afiliación
  • Li J; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China.
  • Xu J; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China.
  • Wang Y; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China.
  • Chen Y; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China.
  • Ding Y; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China.
  • Gao W; School of Pharmacy, Chengdu University, Chengdu, 610106, China.
  • Tan Y; National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Navy Medical University, Shanghai, 201805, China.
  • Ge N; Intervention Center, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, China.
  • Chen Y; National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Navy Medical University, Shanghai, 201805, China.
  • Ge S; National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Navy Medical University, Shanghai, 201805, China.
  • Yang Q; National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Navy Medical University, Shanghai, 201805, China.
  • He B; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China.
  • Ye X; Department of Urology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Adv Mater ; : e2405224, 2024 Aug 09.
Article en En | MEDLINE | ID: mdl-39118578
ABSTRACT
In this work, fusible microspheres loaded with radiopaque agents as an embolic agent for transcatheter arterial embolization (TAE) are developed. A poly(ethylene glycol) (PEG) and poly(ε-caprolactone) (PCL) multi-block copolymer basing polyurethane (PCEU) is synthesized and fabricated into blank microspheres (BMs). The microspheres are elastic in compression test. A clinical contrast agent lipiodol is encapsulated in the microspheres to receive fusible radiopaque microspheres (FRMs). The sizes of FRMs are uniform and range from 142.2 to 343.1 µm. The encapsulated lipiodol acts as the plasticizer to reduce the melting temperature point (Tm) of PECU microspheres, thus, leading to the fusion of microspheres to exhibit efficient embolization in vivo. The performance of FRMs is carried out on a rabbit ear embolization model. Serious ischemic necrosis is observed and the radiopacity of FRMs sustains much longer time than that of commercial contrast agent Loversol in vivo. The fusible and radiopaque microsphere is promising to be developed as an exciting embolic agent.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania