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Does drug-induced liver injury still occur after sevoflurane anesthesia? -A case report.
Lee, Moon Ok; Cho, Seonghyeon; Kim, Chaeeun; Koh, Hanna.
Afiliación
  • Lee MO; Department of Anesthesia and Pain Medicine, Samsung Changwon Hospital, Changwon, Korea.
  • Cho S; Department of Anesthesia and Pain Medicine, Samsung Changwon Hospital, Changwon, Korea.
  • Kim C; Department of Anesthesia and Pain Medicine, Samsung Changwon Hospital, Changwon, Korea.
  • Koh H; Department of Anesthesia and Pain Medicine, Samsung Changwon Hospital, Changwon, Korea.
Anesth Pain Med (Seoul) ; 19(3): 227-232, 2024 Jul.
Article en En | MEDLINE | ID: mdl-39118334
ABSTRACT

BACKGROUND:

Several factors contribute to post-anesthetic hepatic dysfunction, including a decrease in oxygen supply to the liver, direct physical compression of the liver, viral hepatitis, blood transfusions, preexisting hepatic dysfunction, and the use of hepatotoxic drugs. Diagnosing volatile anesthetic drug-induced liver injury (VA-DILI) involves excluding these causes. CASE The patient underwent total mastectomy under anesthesia using sevoflurane. He had diabetes, and no abnormal results were found on preoperative laboratory examinations, and surgery was uneventful. Abnormal laboratory findings were observed after surgery, including an aspartate aminotransferase level of 1,417 IU/L, an alanine aminotransferase level of 2,176 IU/L, and a total bilirubin level of 3.8 mg/dl. He presented with symptoms of mild icteric sclera, fatigue, and pruritus. After ruling out other causes of liver injury, we concluded that these results indicated VA-DILI.

CONCLUSIONS:

VA-DILI, though rare, we should be aware of the association between the disease and the use of halogenated anesthetics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Anesth Pain Med (Seoul) Año: 2024 Tipo del documento: Article Pais de publicación:
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Anesth Pain Med (Seoul) Año: 2024 Tipo del documento: Article Pais de publicación: