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Association between pancreatic adenocarcinoma risk and concentration of organochlorine pesticides in adipose tissue and urine: A targeted-screening analysis case-control study (PESTIPAC).
Brugel, Mathias; Callon, Sidonie; Carlier, Claire; Amroun, Koceila Lamine; Botsen, Damien; Kianmanesh, Reza; Perrier, Marine; Piardi, Tullio; Renard, Yohann; Rhaiem, Rami; El Balkhi, Souleiman; Bouché, Olivier.
Afiliación
  • Brugel M; Gastroenterology and Digestive Oncology Department, Centre Hospitalier Côte Basque, Bayonne, France.
  • Callon S; ULR 2694 - METRICS: Évaluation des Technologies de Santé et des Pratiques Médicales, F-59000, Lille, France.
  • Carlier C; Digestive Oncology Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
  • Amroun KL; Digestive Oncology Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
  • Botsen D; Digestive Oncology Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
  • Kianmanesh R; Department of Medical Oncology, Godinot Cancer Institute, Reims, France.
  • Perrier M; General, Digestive and Endocrine Surgery Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
  • Piardi T; Digestive Oncology Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
  • Renard Y; Department of Medical Oncology, Godinot Cancer Institute, Reims, France.
  • Rhaiem R; General, Digestive and Endocrine Surgery Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
  • El Balkhi S; Gastroenterology and Digestive Oncology Department, Centre Hospitalier Côte Basque, Bayonne, France.
  • Bouché O; General, Digestive and Endocrine Surgery Department, CHU Reims, University of Reims Champagne-Ardenne (URCA), Reims, France.
United European Gastroenterol J ; 12(7): 951-959, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39118264
ABSTRACT

BACKGROUND:

Knowledge about environmental pancreatic adenocarcinoma (PA) risk factors, including pesticide exposure, remains limited. Organochlorine (OC) accumulates in adipose tissue and can help reflect long-term exposure. PATIENTS AND

METHODS:

Age and body mass index (BMI) of patients with PA were matched with those undergoing a surgery for a benign disease on age and BMI (11). Targeted analyses screened 345 pesticides and metabolites, including 29 OC, in adipose tissue and urine samples. The primary aim was to investigate the association between organochlorine concentrations in visceral fat or urine, and PA. Adjusted conditional logistic regressions were carried out accounting for multiple testing.

RESULTS:

Trans-nonachlor (odds ratio [OR] = 1.325, 95% confidence interval [CI] [1.108-1.586]), cis-nonachlor (OR = 15.433, 95% CI [2.733-87.136]), Mirex (OR = 2.853, 95% CI [1.213-6.713]) and 4,4 DDE (OR = 1.019, 95% CI [1.005-1.034]) in fat and a greater number of positive samples (OR = 1.758 95% CI [1.11-2.997]) were significantly associated with higher odds of PA. In contrast, as awaited, urine samples did not yield any statistically significant associations for all tested pesticides.

CONCLUSION:

Some OCs were associated with higher odds of PA. The underlying mechanisms of pancreatic aggression need to be investigated to refine these findings. TRIAL REGISTRATION Clinicaltrials.gov NCT04429490.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Plaguicidas / Adenocarcinoma / Hidrocarburos Clorados Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: United European Gastroenterol J Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Plaguicidas / Adenocarcinoma / Hidrocarburos Clorados Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: United European Gastroenterol J Año: 2024 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido